| Cholecystokinin-induced hypothermia: possible involvement of serotoninergic mechanisms in the rat hypothalamus. | |
| | |
MedLine Citation:
|
PMID: 4023045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The thermal effects of rats which were pretreated with 5,7-dihydroxytryptamine to deplete hypothalamic 5-hydroxytryptamine (5-HT) or with a 5-HT receptor blocker to intrahypothalamic administration of cholecystokinin (CCK) were compared with those of control rats. The CCK-induced hypothermic response was attenuated by pretreatment of the rats with either hypothalamic 5-HT depletion or receptor blockade. The reduction in the CCK hypothermia in the treated rats was due to the reduction of metabolic and vasomotor response. The data indicate that CCK may act on a 5-HT pathway within the hypothalamus to induce its hypothermia by promoting a reduction in metabolic heat production and an enhancement in heat loss in rats. |
| | |
Authors:
|
H J Liu; M T Lin |
Related Documents
:
|
15857665 - Delayed hypothermia preferentially increases expression of brain-derived neurotrophic f... 671345 - The febrile responses in rabbits and rats to leucocyte pyrogens of different species. 971755 - Resistance of cold-exposed rats to aflatoxin. 6117485 - Bombesin, somatostatin, and related peptides: actions on thermoregulation. 2474765 - Effects of disulfiram and coprine on rat brain tryptophan hydroxylation in vivo. 9001735 - Fructose-1,6-bisphosphate after hypoxic ischemic injury is protective to the neonatal r... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pharmacology Volume: 31 ISSN: 0031-7012 ISO Abbreviation: Pharmacology Publication Date: 1985 |
Date Detail:
|
Created Date: 1985-09-23 Completed Date: 1985-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 108-14 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
5,7-Dihydroxytryptamine
/
pharmacology Animals Body Temperature / drug effects* Body Temperature Regulation Catheterization Cholecystokinin / pharmacology* Cyproheptadine / pharmacology Hypothalamus / metabolism, physiology* Male Rats Rats, Inbred Strains Respiration / drug effects Serotonin / metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
|
129-03-3/Cyproheptadine; 31363-74-3/5,7-Dihydroxytryptamine; 50-67-9/Serotonin; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of morphine and naloxone on restraint-stress ulcers in rats.
Next Document: Phentolamine and rat aortic smooth muscle responsiveness to potassium chloride, isoproterenol and no...