Document Detail

Cholecystokinin in the control of gastric acid secretion in humans.
MedLine Citation:
PMID:  7904286     Owner:  NLM     Status:  MEDLINE    
This study was designed to determine the involvement of cholecystokinin (CCK) in the control of gastric acid secretion in men using loxiglumide, a specific CCK-receptor antagonist. Two groups of healthy subjects (A and B) were used: group A for studies of postprandial gastric secretion and group B for studies with exogenous gastric secretagogues. The cephalic phase activated by modified sham feeding (MSF) in group A subjects increased gastric acid secretion to about 36% of pentagastrin maximum, but treatment with loxiglumide in a standard dose (20 mumol/kg i.v. loading dose plus infusion of 20 mumol/kg/h afterwards) failed to affect this secretion. A 5% peptone meal instilled i.g. (to mimic the gastrointestinal phase) greatly enhanced gastric acid secretion and plasma gastrin concentration, but the addition of loxiglumide in a standard dose resulted in a further increase in both gastric acid and plasma gastrin responses to the peptone meal. Plasma somatostatin response to the peptone meal was significantly reduced by loxiglumide. Infusion of cerulein in gradually increasing doses (15-120 pmol/kg/h) and gastrin-releasing peptide (GRP) (25-200 pmol/kg/h) resulted in dose-dependent stimulation of gastric acid secretion, reaching about 35 and 25% of the maximum attained with pentagastrin. When loxiglumide was added the acid responses to cerulein and GRP were further increased by two- to threefold, attaining a peak similar to the pentagastrin maximum. Administration of loxiglumide resulted in a significant increase in plasma gastrin response to GRP, whereas plasma somatostatin was not significantly altered by loxiglumide.(ABSTRACT TRUNCATED AT 250 WORDS)
J W Konturek; M Gutwinska-Konturek; A Gabryelewicz; S J Konturek; W Domschke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  17 Suppl 1     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-02-17     Completed Date:  1994-02-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S40-5     Citation Subset:  IM    
Institute of Physiology, University Medical School, Krakow, Poland.
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MeSH Terms
Caerulein / pharmacology
Cholecystokinin / antagonists & inhibitors,  physiology*
Dose-Response Relationship, Drug
Gastric Acid / secretion*
Gastrin-Releasing Peptide
Gastrins / blood
Peptides / pharmacology
Proglumide / analogs & derivatives,  pharmacology
Receptors, Cholecystokinin / antagonists & inhibitors,  physiology
Somatostatin / blood
Reg. No./Substance:
0/Gastrins; 0/Peptides; 0/Receptors, Cholecystokinin; 107097-80-3/loxiglumide; 17650-98-5/Caerulein; 51110-01-1/Somatostatin; 6620-60-6/Proglumide; 80043-53-4/Gastrin-Releasing Peptide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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