Document Detail

Cholecystokinin and bombesin effects on rewarded and nonrewarded operants.
MedLine Citation:
PMID:  6866804     Owner:  NLM     Status:  MEDLINE    
Rats were food-rationed (15 g/day) and trained to bar-press for food. In Experiment 1, the animals were injected with cholecystokinin octapeptide (CCK, 2 micrograms/day), bombesin (BBS, 12 micrograms/kg), normal saline, or prefed with 20 Noyes 45 mg pellets. The animals were then tested for one hour for bar-pressing responses with food reward. In Experiment 2, the animals were similarly trained, treated, and tested for bar-pressing responses without food reward. The results showed that BBS and prefeeding decreased bar-pressing, rewarded or non-rewarded, but the CCK effect was greatly decreased when food was withheld. It appeared that the CCK effect was more dependent upon the presence of food than the BBS or prefeeding effects. The results were discussed in terms of involvement of the food and reward-related oropharyngeal stimuli for the CCK effect and the drive-related stimuli for the BBS and prefeeding effects.
S Hsiao; D Deupree
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  4     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1983 Jan-Feb
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-3     Citation Subset:  IM    
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MeSH Terms
Bombesin / pharmacology*
Cholecystokinin / pharmacology*
Conditioning, Operant / drug effects*
Peptides / pharmacology*
Rats, Inbred F344
Time Factors
Grant Support
Reg. No./Substance:
0/Peptides; 9011-97-6/Cholecystokinin; PX9AZU7QPK/Bombesin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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