Document Detail

Cholecystokinin and bombesin act independently to decrease food intake in the rat.
MedLine Citation:
PMID:  6276871     Owner:  NLM     Status:  MEDLINE    
The satiating effects of cholecystokinin-octapeptide (CCK-8) and bombesin (BBS) when injected alone and in combination were compared in intact rats. When injected alone, both CCK-8 and BBS elicited a dose-related decrease of 30-minute food intake. Injections of BBS were less potent than the equivalent doses of CCK-8 in producing satiety. BBS reached an asymptotic level of suppression of approximately 40 percent at a dose of 2 micrograms/kg, whereas injections of 4 micrograms/kg of CCK-8 resulted in a 72 percent suppression of food intake. When the two peptides were administered in a single injection, the resulting suppression of food intake was equivalent to that which would be predicted if their effects were completely additive. These results support the hypothesis that CCK-8 and BBS act via independent mechanisms to induce satiety. A preliminary model of peptidergic satiety, based on this hypothesis, is proposed.
L J Stein; S C Woods
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  2     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1981  
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
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MeSH Terms
Bombesin / pharmacology*
Cholecystokinin / pharmacology*
Dose-Response Relationship, Drug
Eating / drug effects*
Peptide Fragments / pharmacology*
Peptides / pharmacology*
Rats, Inbred Strains
Satiation / drug effects
Grant Support
Reg. No./Substance:
0/Peptide Fragments; 0/Peptides; 25126-32-3/Sincalide; 31362-50-2/Bombesin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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