Document Detail


Cholecystokinin antibody injected in cerebral ventricles stimulates feeding in sheep.
MedLine Citation:
PMID:  7221559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of brain cholecystokinin peptides in satiety was further assessed by using antibody to cholecystokinin to reduce cholecystokinin activity in the cerebrospinal fluid of sheep. Food intakes were increased approximately 100 percent during the 2-hour continuous injection of antibody into the cerebrospinal fluid. This supports the hypothesis that, during feeding, cholecystokinin is released into the cerebrospinal fluid, which transports it to the receptors that elicit satiety.
Authors:
M A Della-Fera; C A Baile; B S Schneider; J A Grinker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  212     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  687-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies / administration & dosage
Antigen-Antibody Reactions
Castration
Cholecystokinin / cerebrospinal fluid,  immunology,  physiology*
Feeding Behavior / physiology*
Injections, Intraventricular
Male
Satiation / physiology*
Sheep
Grant Support
ID/Acronym/Agency:
GM 02051/GM/NIGMS NIH HHS; NS 06595/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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