Document Detail


Cholecystokinin antagonism by benzodiazepines in the food intake in mice.
MedLine Citation:
PMID:  2869533     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three benzodiazepines, chlordiazepoxide, diazepam and flurazepam, were demonstrated to reverse the suppressed food intake in mice in response to cholecystokinin octapeptide (CCK8). CCK8 (200 ng) was administered intracisternally, and the benzodiazepines intraperitoneally at doses of 0.1 to 1 mg/kg. The three benzodiazepines slightly depressed the feeding by themselves, but significantly reversed the satiety effects of CCK8. Naloxone (2 mg/kg) decreased the food intake but failed to reverse the CCK8 satiety action. The benzodiazepines were considered to antagonize the satiety action of CCK8 in the central nervous system through unknown mechanisms.
Authors:
K Kubota; I Matsuda; K Sugaya; T Uruno
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  36     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-10     Completed Date:  1986-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  175-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Anxiety Agents / pharmacology*
Chlordiazepoxide / pharmacology
Diazepam / pharmacology
Eating / drug effects*
Flurazepam / pharmacology
Injections, Intraperitoneal
Male
Mice
Naloxone / pharmacology
Sincalide / antagonists & inhibitors*
Subarachnoid Space
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; 17617-23-1/Flurazepam; 25126-32-3/Sincalide; 439-14-5/Diazepam; 465-65-6/Naloxone; 58-25-3/Chlordiazepoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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