| Cholecystokinin as a regulator of cardiac function and postprandial gastrointestinal blood flow in rainbow trout (Oncorhynchus mykiss). | |
| | |
MedLine Citation:
|
PMID: 20164206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have studied the potential role of CCK as a regulator/modulator of the postprandial increase in gastrointestinal blood flow. Rainbow trout (Oncorhynchus mykiss) were instrumented with pulsed Doppler flow probes to measure the effects of CCK on cardiac output and gastrointestinal blood flow. Furthermore, vascular preparations were used to study the direct effects of CCK on the vessels. In addition, we used in situ perfused hearts to further study the effects of CCK on the cardiovascular system. When the sulfated form of CCK-8 was injected at a physiological concentration (0.19 pmol/kg) in vivo, there was a significant increase in the gastrointestinal blood flow (18 +/- 4%). This increase in gastrointestinal blood flow was followed by a subsequent increase in cardiac output (30 +/- 6%). When the dose was increased to 0.76 pmol/kg, there was only a 14 +/- 6% increase in gastrointestinal blood flow; possibly due to a dose-dependent increase in the gill vascular resistance as previously reported or a direct effect on the heart. Nevertheless, CCK did not affect the isolated vessel preparations, and thus, it seems unlikely that CCK has a direct effect on the blood vessels of the second or third order. CCK did, however, have profound effects on the dynamics of the heart, and without a change in cardiac output, there was a significant increase in the amplitude (59 +/- 4%) and rate (dQ/dt: 55 +/- 4%; -dQ/dt: 208 +/- 49%) of the phasic flow profile. If and how this might be coupled to a postprandial gastrointestinal hyperemia remains to be determined. We conclude that CCK has the potential as a regulator of the postprandial gastrointestinal blood flow in fish and most likely has its effect by inducing a gastrointestinal hyperemia. The mechanism by which CCK acts is at present unknown. |
| | |
Authors:
|
Henrik Seth; Albin Gräns; Michael Axelsson |
Related Documents
:
|
17994316 - Pilot study on the influence of liver blood flow and cardiac output on the clearance of... 7546996 - Assessment of magnetic resonance velocity mapping of global ventricular function during... 759086 - Mic-ii - a program for the determination of cardiac output, arterio-venous shunt and re... 16913336 - Effect of low-dose vasopressin infusion on vital organ blood flow in the conscious norm... 9709786 - High prevalence in central africa of blood donors who are potentially infectious for hu... 3293916 - Cardiopulmonary effect of various inspiratory flow profiles during controlled mechanica... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-17 |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 298 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-08-17 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: R1240-8 Citation Subset: IM |
Affiliation:
|
Department of Zoology, University of Gothenburg, Gothenburg, Sweden. henrik.seth@zool.gu.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Sequence Animals Cardiac Output / drug effects, physiology* Conserved Sequence Diastole / drug effects, physiology Gastrointestinal Agents / metabolism, pharmacology Gastrointestinal Tract / blood supply*, physiology Hyperemia / chemically induced, physiopathology Oncorhynchus mykiss / physiology* Postprandial Period / drug effects, physiology Regional Blood Flow / drug effects, physiology* Sincalide* / genetics, metabolism, pharmacology Systole / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Gastrointestinal Agents; 25126-32-3/Sincalide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Connexins and the kidney.
Next Document: Characterization of a "Spinal - Urine Storage Reflex - Inhibitory Center" (SUSRIC) and Its Regulatio...