Document Detail


Cholecystokinin-58 is more potent in inhibiting food intake than cholecystokinin-8 in rats.
MedLine Citation:
PMID:  18510806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Several cholecystokinin (CCK) forms have been detected in plasma, but most studies on food intake investigated the effects of CCK-8 only. Recently, it has been demonstrated that CCK-58 is the only endocrine-active form of CCK in rats. METHODS: CCK-58 was synthesized with a peptide synthesizer using FMOC chemistry and CCK-58 effects on food intake were compared to CCK-8 in rats. RESULTS: Both CCK-58 and CCK-8 inhibited food intake in a dose-dependent manner and were equally potent at 30 min. CCK-58 showed a prolonged inhibition of food intake compared to CCK8 at the higher dose tested (7 nmol/kg), inhibiting food intake also at 60 min, and cumulative food intake was inhibited for up to 210 min by CCK-58. CONCLUSIONS: CCK-58 has the same potency in inhibiting food intake as CCK-8 in rats, but inhibits food intake longer. This might be due to its tertiary structure resulting in a delayed plasma degradation or a prolonged binding at the CCK receptor. As CCK-58 is the major CCK form in the gut wall and possibly in the circulating blood in humans, the effects of CCK on food intake might have been underestimated in the past.
Authors:
Joerg Glatzle; Helen E Raybould; Markus A Kueper; Joseph R Reeve; Tilman T Zittel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  11     ISSN:  1476-8305     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-30     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  69-74     Citation Subset:  IM    
Affiliation:
Department of General and Transplantation Surgery, University Hospital, University of Tübingen, Germany. joerg.glatzle@med.uni-tuebingen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholecystokinin / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Eating / drug effects*
Kinetics
Male
Rats
Rats, Sprague-Dawley
Sincalide / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
25126-32-3/Sincalide; 83381-92-4/cholecystokinin 58; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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