Document Detail

Cholecystokinin-58 and cholecystokinin-8 produce similar but not identical activations of myenteric plexus and dorsal vagal complex.
MedLine Citation:
PMID:  18455815     Owner:  NLM     Status:  MEDLINE    
The enteric nervous system (ENS: myenteric and submucosal plexuses) of the gastrointestinal tract may have a role in the reduction of food intake by cholecystokinin (CCK). Exogenous cholecystokinin-8 (CCK-8) activates the myenteric plexus and the feeding control areas of the dorsal vagal complex (DVC) of the brainstem. An increasing number of reports, however, have shown that CCK-58 is the sole or the major circulating form of CCK in rat, human and dog, and that it is qualitatively different from CCK-8 in evoking various gastrointestinal physiological responses (e.g., contraction of the gallbladder and exocrine pancreatic secretion). In the current report, we compared the abilities of exogenous CCK-58 to activate the myenteric plexus and the dorsal vagal complex with those of exogenous CCK-8 by quantifying Fos-like immunoreactivity (Fos-LI; a marker for neuronal activation). We report that CCK-58 (1, 3, and 5 nmol/kg) increased Fos-LI in the myenteric plexus (p<0.001) and in the DVC (p<0.001) compared to the saline vehicle. The highest dose of CCK-58 increased Fos-LI more than an equimolar dose of CCK-8 in the myenteric plexus and the area postrema. Thus, CCK-8 and CCK-58 produce the same qualitative pattern of activation of central and peripheral neurons, but do not provoke identical quantitative patterns at higher doses. The different patterns produced by the two peptides at higher doses, in areas open to the circulation (myenteric plexus and area postrema) may reflect endocrine actions not observed at lower doses.
Marvis S Cooper; Joseph R Reeve; Shannon J Raboin; Mohamed O Abdalla; Gary M Green; Ayman I Sayegh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-03-26
Journal Detail:
Title:  Regulatory peptides     Volume:  148     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  88-94     Citation Subset:  IM    
Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama, USA.
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MeSH Terms
Cholecystokinin / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Feeding Behavior / drug effects
Myenteric Plexus / cytology,  drug effects*,  metabolism
Peptide Fragments / administration & dosage,  pharmacology*
Proto-Oncogene Proteins c-fos / metabolism
Rats, Sprague-Dawley
Vagus Nerve / cytology,  drug effects*,  metabolism
Grant Support
Reg. No./Substance:
0/Peptide Fragments; 0/Proto-Oncogene Proteins c-fos; 0/cholecystokinin 8; 0/fos-related antigen 1; 83381-92-4/cholecystokinin 58; 9011-97-6/Cholecystokinin

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