Document Detail


Cholecystokinin-33 is more effective than cholecystokinin-8 in inhibiting food intake and in stimulating the myenteric plexus and dorsal vagal complex.
MedLine Citation:
PMID:  18346716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared the abilities of cholecystokinin-33 (CCK-33) and CCK-8 to reduce food intake and to activate feeding-related areas of the nervous system. (1) Overnight food-deprived rats were presented with a 10% sucrose solution, and intake was measured at 5-min intervals throughout a 90-min test beginning immediately after intraperitoneal injections of 1, 3, or 5 nMol/kg of CCK-33, CCK-8, or the vehicle control. In the initial 20 min (first meal), both peptides were equally effective, producing large reductions of food intake. Thereafter, however, CCK-33 was more effective than CCK-8, producing much more sustained reductions. Overall, both peptides reduced total food intake, but CCK-33 was more effective than CCK-8. (2) Possible roles for the myenteric plexus of the duodenum and the dorsal vagal complex (DVC) of the brainstem in the differential satiety effects of CCK-33 and CCK-8 were examined by quantifying CCK-33- and CCK-8-stimulated Fos-like immunoreactivity (Fos-LI) in each site. Consistent with the greater ability of CCK-33 to produce sustained inhibitions of food intake, CCK-33 produced more Fos-LI than CCK-8 in nearly every section of the sampled sites. The results demonstrate: (1) Different forms of CCK have different efficacies in reducing food intake; (2) CCK-33 produces a much more prolonged satiety action than CCK-8; and (3) the myenteric plexus and DVC may play roles in these differential satiety actions.
Authors:
Marvis S Cooper; Joseph R Reeve; Mohamed O Abdalla; Laura Moyer; Shannon J Raboin; Gary M Green; Ayman I Sayegh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-03-17
Journal Detail:
Title:  Brain research     Volume:  1205     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-07-22     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  27-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / pharmacology*
Cell Count
Cholecystokinin / pharmacology*
Eating / drug effects*
Immunohistochemistry
Male
Myenteric Plexus / drug effects*
Peptide Fragments / pharmacology*
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Sprague-Dawley
Solitary Nucleus / cytology,  drug effects
Vagus Nerve / drug effects*
Grant Support
ID/Acronym/Agency:
DK-41301/DK/NIDDK NIH HHS; P30 DK041301/DK/NIDDK NIH HHS; R01 DK033850/DK/NIDDK NIH HHS; R01-DK33850/DK/NIDDK NIH HHS; S06/GM08091-31/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Peptide Fragments; 0/Proto-Oncogene Proteins c-fos; 0/cholecystokinin 8; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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