| Cholangiocarcinoma--controversies and challenges. | |
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MedLine Citation:
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PMID: 21460876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholangiocarcinomas are a diverse group of tumors that are presumed to originate from the biliary tract epithelium either within the liver or the biliary tract. These cancers are often difficult to diagnose, their pathogenesis is poorly understood, and their dismal prognosis has resulted in a nihilistic approach to their management. The two major clinical phenotypes are intrahepatic, mass-forming tumors and large ductal tumors. Among the ductal cancers, lesions at the liver hilum are most prevalent. The risk factors, clinical presentation, natural history and management of these two types of cholangiocarcinoma are distinct. Efforts to improve outcomes for patients with these diseases are affected by several challenges to effective management. For example, designations based on anatomical characteristics have been inconsistently applied, which has confounded analysis of epidemiological trends and assessment of risk factors. The evaluation of therapeutic options, particularly systemic therapies, has been limited by a lack of appreciation of the different phenotypes. Controversies exist regarding the appropriate workup and choice of management approach. However, new and emerging tools for improved diagnosis, expanded indications for surgical approaches, an emerging role for locoregional and intrabiliary therapies and improved systemic therapies provide optimism and hope for improved outcomes in the future. |
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Authors:
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Tushar Patel; |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Nature reviews. Gastroenterology & hepatology Volume: 8 ISSN: 1759-5053 ISO Abbreviation: Nat Rev Gastroenterol Hepatol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-07-21 Revised Date: 2012-04-12 |
Medline Journal Info:
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Nlm Unique ID: 101500079 Medline TA: Nat Rev Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 189-200 Citation Subset: IM |
Affiliation:
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Department of Transplantation, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. patel.tushar@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bile Duct Neoplasms
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epidemiology,
pathology,
therapy* Bile Ducts, Intrahepatic* Cholangiocarcinoma / epidemiology, pathology, therapy* Combined Modality Therapy Humans Neoplasm Staging Phenotype Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK069370-08/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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