Document Detail

Cholangiocarcinoma associated with multiple bile-duct hamartomas of the liver.
MedLine Citation:
PMID:  2470558     Owner:  NLM     Status:  MEDLINE    
The case of a 61-year-old woman with a surgically resected solitary cholangiocarcinoma of the liver is reported, where many discrete multiple bile duct hamartoma (MBDH) were also seen. The latter is a congenital lesion of the liver that potentially may be confused with widespread metastatic disease. The relationship between cholangiocarcinoma and MBDH was studied histologically by the use of an immunoperoxidase technique for cytokeratin. MBDH was strongly positive for cytokeratin, while the neoplasm showed this to a lesser extent, but a clear continuity between the MBDH epithelial cells and those of the neoplasm was demonstrated by the use of this technic. The potential use for the various cytokeratins in the differentiation of primary from secondary liver tumors, is discussed. This differentiation is a significant problem to the pathologist. Although cholangiocarcinoma may, on occasion, be associated with various congenital lesions of the bile ducts, the association with MBDH is extremely rare, this being only the third reported case.
A Dekker; F J Ten Kate; O T Terpstra
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  34     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-12     Completed Date:  1989-07-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  952-8     Citation Subset:  AIM; IM    
Department of Pathology, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Adenoma, Bile Duct / analysis,  pathology*
Bile Duct Neoplasms / analysis,  pathology*
Bile Ducts / abnormalities
Bile Ducts, Intrahepatic
Carcinoembryonic Antigen / analysis
Hamartoma / analysis,  pathology*
Keratins / analysis
Liver Neoplasms / analysis,  pathology*
Membrane Glycoproteins / analysis
Middle Aged
Neoplasms, Multiple Primary*
Reg. No./Substance:
0/Carcinoembryonic Antigen; 0/Membrane Glycoproteins; 0/Mucin-1; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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