Document Detail


Choice of sevoflurane and its subjective and psychomotor effects in light and moderate drinkers.
MedLine Citation:
PMID:  18077105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sevoflurane, an inhalant of the volatile anesthetic class, has neurobiological and behavioral effects in common with abused inhalants and ethanol. We sought to determine if choice for subanesthetic doses of sevoflurane, and its subjective and psychomotor effects, would differ as a function of alcohol-drinking status in healthy volunteers.
METHODS: The effects of four concentrations of sevoflurane (0, 0.2, 0.4, 0.8% sevoflurane in oxygen) were studied in 16 light drinkers and 16 moderate drinkers. During each of four sessions, subjects sampled a concentration of sevoflurane and 100% O(2) (placebo) for 10 min each. Subjective and psychomotor testing commenced 5 min into each sampling trial. Later, within the session, subjects chose nine times, once every 5 min, among sevoflurane (e.g., "Agent A"), placebo (e.g., "Agent B," 100% O(2)), or neither (and were administered 100% O(2), identified as "drug-free air").
RESULTS: Choice for sevoflurane at the 0.4% concentration was significantly higher in the moderate drinkers than in the light drinkers. A number of subjective effects reported during inhalation of sevoflurane were markedly lower in the moderate-drinking group than in the light-drinking group. However, psychomotor impairment induced by sevoflurane was similar in magnitude in both groups.
CONCLUSIONS: Alcohol-drinking status affected sevoflurane choice. The results are consistent with several studies comparing light and heavier drinkers, using other drugs. Although both drinking groups were similarly impaired by sevoflurane, the moderate drinkers reported less of a subjective response than light drinkers, suggestive of cross-tolerance.
Authors:
James P Zacny; Diana J Walker; Melinda Drum; Molly Sells
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  94     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-02-22     Completed Date:  2008-06-27     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  101-8     Citation Subset:  IM    
Affiliation:
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA. jzacny@dacc.uchicago.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / epidemiology*
Anesthetics, Inhalation / administration & dosage*,  pharmacology*
Choice Behavior*
Female
Humans
Male
Methyl Ethers / administration & dosage*,  pharmacology*
Prevalence
Psychomotor Performance / drug effects*
Reinforcement (Psychology)
Substance-Related Disorders / epidemiology*
Grant Support
ID/Acronym/Agency:
DA015934/DA/NIDA NIH HHS; DA08391/DA/NIDA NIH HHS; R01 DA008391-11/DA/NIDA NIH HHS; R01 DA015934-05/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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