Document Detail


Choice between cocaine and food by rhesus monkeys: effects of conditions of food availability.
MedLine Citation:
PMID:  11224164     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The present experiment was designed to examine the effects of the conditions of food availability on choice between cocaine and food in rhesus monkeys. Monkeys (n = 3), maintained at approximately 90% of their free-feeding weights, were trained in a discrete-trials choice procedure and allowed to choose between intravenous injections of cocaine (0.03-1.0mg/kg/injection) and food delivery (4 pellets; 1g/pellet) during daily 7-h sessions. When food was available both within the session and by supplemental post-session feeding, the frequency of cocaine choice increased in a dose-related manner for all monkeys. When supplemental post-session feeding was eliminated (i.e. food was only available within the session) the cocaine dose-response function was shifted to the right and down relative to that found initially. However, changes in the frequency of cocaine choice did not vary consistently with changes in body weight. Thus, these results suggest that the reinforcing efficacy of cocaine can be modified by changing the conditions of availability of an alternative non-drug reinforcer.
Authors:
M.A. Nader; W.L. Woolverton
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  3     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  1992 Dec 
Date Detail:
Created Date:  2001-Feb-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  635-638     Citation Subset:  -    
Affiliation:
Drug Abuse Research Center, Department of Psychiatry, Pritzker School of Medicine, The University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA.
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