| Choice of antibiotics in late neonatal sepsis in the extremely low birth weight infant. | |
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MedLine Citation:
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PMID: 18159422 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review the choice of antibiotics in treating suspected late neonatal sepsis in infants weighing 1000 g or less in a neonatal intensive care unit. METHODS: Retrospective review of medical records. RESULTS: Ninety-six infants weighing 1000 g or less were admitted to the neonatal intensive care unit during the study period. Sixty-two infants survived beyond four days of life and had at least one sepsis workup done to exclude late neonatal infection. Of the 62 study patients, 42 (68%) were started on ampicillin and netilmicin (A/N) and 20 (32%) were started on vancomycin and ceftizoxime (V/C) as the antibiotics of choice, pending culture results. Of the patients started on A/N, 17 of 42 had a positive blood culture compared with 11 of 20 on V/C (40% versus 55%, P=0.40). The mean (+/-SD) birth weight of infants started on A/N was 793+/-133 g compared with a mean of 728+/-153 g in the group that received V/C (P=0.09). Seven patients died in the A/N group compared with three in the V/C group (16.7% versus 15%, P=0.84). In addition to the sepsis episode studied, before they were discharged from hospital, 21 of 42 (50%) infants in the A/N group had further workups for suspected sepsis, compared with 16 of 20 (80%) (P=0.048) infants initially given V/C. CONCLUSIONS: Ampicillin and netilmicin is a safe antibiotic combination for neonates suspected of late sepsis. This, in turn, may be important in reducing vancomycin overuse and the potential for bacterial resistance to this antimicrobial agent. |
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Authors:
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Tara R Allen; Orlando P da Silva |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses Volume: 14 ISSN: 1180-2332 ISO Abbreviation: Can J Infect Dis Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2007-12-26 Completed Date: 2011-07-14 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 9425856 Medline TA: Can J Infect Dis Country: Canada |
Other Details:
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Languages: eng Pagination: 28-31 Citation Subset: - |
Affiliation:
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Joseph's Health Care London, Department of Paediatrics, Child Health Research Institute, University of Western Ontario, London, Ontario. |
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