| Chocolate intake and incidence of heart failure: a population-based prospective study of middle-aged and elderly women. | |
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MedLine Citation:
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PMID: 20713904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Randomized clinical trials have shown that chocolate intake reduces systolic and diastolic blood pressure, and observational studies have found an inverse association between chocolate intake and cardiovascular disease. The aim of this study was to investigate the association between chocolate intake and incidence of heart failure (HF). METHODS AND RESULTS: We conducted a prospective cohort study of 31,823 women aged 48 to 83 years without baseline diabetes or a history of HF or myocardial infarction who were participants in the Swedish Mammography Cohort. In addition to answering health and lifestyle questions, participants completed a food-frequency questionnaire. Women were followed from January 1, 1998, through December 31, 2006, for HF hospitalization or death through the Swedish inpatient and cause-of-death registers. Over 9 years of follow-up, 419 women were hospitalized for incident HF (n=379) or died of HF (n=40). Compared with no regular chocolate intake, the multivariable-adjusted rate ratio of HF was 0.74 (95% CI, 0.58 to 0.95) for women consuming 1 to 3 servings of chocolate per month, 0.68 (95% CI, 0.50 to 0.93) for those consuming 1 to 2 servings per week, 1.09 (95% CI, 0.74 to 1.62) for those consuming 3 to 6 servings per week, and 1.23 (95% CI, 0.73 to 2.08) for those consuming ≥1 servings per day (P=0.0005 for quadratic trend). CONCLUSIONS: In this population, moderate habitual chocolate intake was associated with a lower rate of HF hospitalization or death, but the protective association was not observed with intake of ≥1 servings per day. |
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Authors:
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Elizabeth Mostofsky; Emily B Levitan; Alicja Wolk; Murray A Mittleman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-16 |
Journal Detail:
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Title: Circulation. Heart failure Volume: 3 ISSN: 1941-3297 ISO Abbreviation: Circ Heart Fail Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2010-10-14 Revised Date: 2011-10-27 |
Medline Journal Info:
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Nlm Unique ID: 101479941 Medline TA: Circ Heart Fail Country: United States |
Other Details:
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Languages: eng Pagination: 612-6 Citation Subset: IM |
Affiliation:
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Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Analysis of Variance Cacao* Chi-Square Distribution Female Heart Failure / epidemiology*, prevention & control Humans Incidence Middle Aged Monte Carlo Method Proportional Hazards Models Prospective Studies Questionnaires Registries Sweden / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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F32 HL091683/HL/NHLBI NIH HHS; F32 HL091683-02/HL/NHLBI NIH HHS; T32 A1007535-11//PHS HHS; T32 AI007535-11A1/AI/NIAID NIH HHS |
| Comments/Corrections | |
Comment In:
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Circ Heart Fail. 2011 Jan;4(1):e5; author reply e6
[PMID:
21245453
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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