Document Detail


Chlorzoxazone hepatotoxic reactions. An analysis of 21 identified or presumed cases.
MedLine Citation:
PMID:  3521519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A drug rechallenge proved chlorzoxazone to be hepatotoxic in a patient who had been treated with a combination of it and acetaminophen (Parafon Forte) for several months. Failure to demonstrate a toxic response to acetaminophen coupled with a dramatic response to a single dose of chlorzoxazone implicated chlorzoxazone as the hepatotoxic agent. A review of US Food and Drug Administration records and cases reported in the medical literature disclosed 23 cases of chlorzoxazone-associated hepatotoxic reactions occurring since 1970. These cases were examined in terms of age, duration of therapy, other confounding etiologic factors, and ultimate outcome. There were two deaths involving hepatic failure. Reports of adverse reactions among six commonly used analgesic-muscle relaxants in Sweden have indicated a low, but comparatively greater, incidence of hepatotoxic reactions associated with a chlorzoxazone-containing compound.
Authors:
B J Powers; E L Cattau; H J Zimmerman
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Archives of internal medicine     Volume:  146     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-03     Completed Date:  1986-07-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1183-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / adverse effects
Adult
Aged
Benzoxazoles / adverse effects*
Biopsy
Chlorzoxazone / adverse effects*
Drug Combinations
Drug Evaluation
Female
Humans
Liver / drug effects*,  pathology
Male
Middle Aged
Necrosis
Time Factors
Chemical
Reg. No./Substance:
0/Benzoxazoles; 0/Drug Combinations; 103-90-2/Acetaminophen; 95-25-0/Chlorzoxazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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