| Chlorpropamide-induced hyponatremia in the veteran population. | |
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MedLine Citation:
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PMID: 1421649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the incidence and possible risk factors associated with chlorpropamide (CPA)-induced hyponatremia in the veteran population. DESIGN: Retrospective cohort study. SETTING: Federal tertiary care medical center. PATIENTS: Veterans receiving CPA from our facility with at least one serum sodium concentration below 135 mmol/L within the past year were eligible. A randomly selected control group consisting of patients taking CPA with normal sodium concentrations was also chosen. One hundred forty-five of 799 patients who had received CPA were included in the study. RESULTS: The average daily dose of CPA was 425 +/- 207 mg (+/- SD). The incidence of hyponatremia associated with CPA was 7.1 percent (57/799 patients). The majority of patients were mildly hyponatremic (48/57 patients, 84 percent) with serum sodium concentrations between 130 and 134 mmol/L. The incidence of CPA-induced syndrome of inappropriate antidiuretic hormone was 2.1 percent. Concurrent angiotensin-converting enzyme (ACE) inhibitor use was identified as a risk factor; thiazide diuretic use was not. CONCLUSIONS: The incidence of hyponatremia related to CPA use in elderly veterans is consistent with other reports in the literature. ACE inhibitors may be a predisposing factor for CPA-induced hyponatremia. |
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Authors:
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C A Hirokawa; D R Gray |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 26 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-12-16 Completed Date: 1992-12-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1243-4 Citation Subset: IM |
Affiliation:
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Department of Veterans Affairs Medical Center, Long Beach, CA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiotensin-Converting Enzyme Inhibitors / administration & dosage California / epidemiology Chlorpropamide / adverse effects* Cohort Studies Female Humans Hyponatremia / chemically induced*, epidemiology Inappropriate ADH Syndrome / chemically induced*, epidemiology Incidence Male Middle Aged Retrospective Studies Risk Factors Veterans |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 94-20-2/Chlorpropamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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