Document Detail


Chlorpromazine specifically prevents the wheel-induced feeding suppression in rats.
MedLine Citation:
PMID:  19549534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In rats, limited daytime wheel access suppresses feeding over the subsequent night [Lattanzio SB, Eikelboom R. Wheel access duration in rats: I. effects on feeding and running. Behav Neurosci 2003; 117:496-504.]. This phenomenon is known as the wheel-induced feeding suppression (WIFS). The classic antipsychotic, chlorpromazine, can minimize the severity of the related activity anorexia procedure, but is thought to act through a suppression of running [Routtenberg A. "Self-starvation" of rats living in activity wheels: adaptation effects. J Comp Physiol Psychol 1968; 66:234-8.]. We tested the effects of chlorpromazine (2mg/kg IP) on the acute WIFS in 40 adult male rats by administering the drug before or after 3h of daytime wheel access and measuring food consumption over the subsequent 24h. Control groups received saline injections or were exposed to locked wheels. While chlorpromazine did not attenuate feeding or change wheel running alone, it blocked their interaction, the acute WIFS. This procedure might be useful in screening drugs for anorexia nervosa where exercise is often elevated and feeding is suppressed.
Authors:
Kerry L Adams; Graham G Parfeniuk; Roelof Eikelboom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-21
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  93     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  470-3     Citation Subset:  IM    
Affiliation:
Department of Psychology, Wilfrid Laurier University, Waterloo ON, Canada N2L 3C5.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects,  physiology
Chlorpromazine / pharmacology*
Dopamine Antagonists / pharmacology*
Drinking / drug effects,  physiology
Eating / drug effects,  physiology
Feeding Behavior / drug effects*
Male
Motor Activity / physiology
Physical Conditioning, Animal / psychology*
Rats
Rats, Sprague-Dawley
Running / physiology
Chemical
Reg. No./Substance:
0/Dopamine Antagonists; 50-53-3/Chlorpromazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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