Document Detail

Chlorpromazine-induced electrocardiogram abnormalities.
MedLine Citation:
PMID:  1099023     Owner:  NLM     Status:  MEDLINE    
The aim of our clinical investigation was to evaluate the electrocardiographic abnormalities in patients receiving only chlorpromazine, and to assess the role of sex, age and length of illness in these abnormalities. 96 schizophrenic patients (48 male and 48 female patients) satisfying study criteria were selected for inclusion and changed from their old medication to a fixed dose of 125 mg chlorpromazine daily. This uniformization period lasted two weeks, during which the electrocardiograms were taken after an overnight fast. Five patients were excluded because their electrocardiographic changes revealed the possibility of an organic heart disease. The electrocardiograms were found to be normal for 65.9% of the patients and abnormal for 34.1%. 11% of patients were classified as demonstrating Grade I repolarization abnormalities, 14.3% of patients as Grade II, and 8.8% as Grade III. Chi square (X2) tests revealed no significant differences between sexes, age groups or lenghts of illness as regards ECG normality and grade of abnormality.
G Chouinard; L Annable; Melançon; M Chabot
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology and biopharmacy     Volume:  11     ISSN:  0340-0026     ISO Abbreviation:  Int J Clin Pharmacol Biopharm     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-11-22     Completed Date:  1975-11-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7505527     Medline TA:  Int J Clin Pharmacol Biopharm     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  IM    
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MeSH Terms
Age Factors
Chlorpromazine / adverse effects*,  therapeutic use
Clinical Trials as Topic
Heart / drug effects
Middle Aged
Schizophrenia / drug therapy,  physiopathology
Sex Factors
Reg. No./Substance:

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