Document Detail

Chlorozotocin (DCNU)--induced pulmonary toxicity.
MedLine Citation:
PMID:  6459189     Owner:  NLM     Status:  MEDLINE    
A case of pulmonary toxicity after chlorozotocin (DCNU) is described. This patient developed shortness of breath, nonproductive cough, and interstitial infiltrates after his third dose of DCNU. This was documented on pulmonary function tests which showed a reduction in vital capacity and pulmonary diffusion capacity. Similar findings have been reported in restrictive pulmonary disease associated with other nitrosoureas. This is the first case reported of pulmonary toxicity induced by DCNU.
E M Sordillo; P P Sordillo; D Stover; G B Magill
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer clinical trials     Volume:  4     ISSN:  0190-1206     ISO Abbreviation:  Cancer Clin Trials     Publication Date:  1981  
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905482     Medline TA:  Cancer Clin Trials     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-9     Citation Subset:  IM    
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MeSH Terms
Fibrosarcoma / drug therapy*,  secondary
Lung Neoplasms / drug therapy*,  secondary
Middle Aged
Pulmonary Fibrosis / chemically induced*
Respiratory Function Tests
Streptozocin / adverse effects,  analogs & derivatives*,  therapeutic use
Grant Support
Reg. No./Substance:
18883-66-4/Streptozocin; 54749-90-5/chlorozotocin

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