Document Detail


Chloroxylenol- and triclosan-tolerant bacteria from industrial sources.
MedLine Citation:
PMID:  12407457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Potential development of bacterial tolerance to biocides in the industrial environment is examined in this study. Bacteria tolerant to the phenolic-type agent para-chloro-meta-xylenol (PCMX) and the bis-phenol 2,4,4'-trichloro-2'-hydroxydiphenylether (triclosan) were isolated from industrial sources and identified. Minimum inhibitory concentrations (MICs) were determined and compared with those of culture collection (standard) strains. Of around 100 isolates originally obtained, most were naturally tolerant species such as Pseudomonas spp., or showed low tolerance levels. PCMX-tolerant isolates of Pseudomonas stutzeri and triclosan-tolerant isolates of Citrobacter freundii and Acinetobacter johnsonii were retained for further study. Of these, only P. stutzeri and A. johnsonii showed elevated tolerance compared with the standard strains. There was no evidence of tolerance to the other biocide except for Pseudomonas aeruginosa (an intrinsically tolerant microorganism), and tolerances were stable in the absence of selective pressure except for A. johnsonii. Attempts to select or generate increased tolerance in the standard strains were unsuccessful. High tolerances in terms of MIC were not reflected in terms of lethal effects. This study did not produce any evidence suggesting that the presence of residual biocide concentrations in the industrial environment promotes the emergence of bacterial tolerance for them.
Authors:
J C Lear; J-Y Maillard; P W Dettmar; P A Goddard; A D Russell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of industrial microbiology & biotechnology     Volume:  29     ISSN:  1367-5435     ISO Abbreviation:  J. Ind. Microbiol. Biotechnol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-30     Completed Date:  2003-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9705544     Medline TA:  J Ind Microbiol Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  238-42     Citation Subset:  IM    
Affiliation:
Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, UK.
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MeSH Terms
Descriptor/Qualifier:
Bacteria / drug effects*
Disinfectants / pharmacology*
Drug Resistance, Bacterial
Industry
Microbial Sensitivity Tests
Triclosan / pharmacology*
Xylenes / pharmacology*
Chemical
Reg. No./Substance:
0/Disinfectants; 0/Xylenes; 3380-34-5/Triclosan; 88-04-0/chloroxylenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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