Document Detail


Chloroquine-resistant Plasmodium falciparum cerebral malaria in a chloroquine-susceptible area.
MedLine Citation:
PMID:  10515845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chloroquine-resistant Plasmodium falciparum is endemic in many areas. Saudi Arabia was considered to have chloroquine-susceptible P. falciparum. During the 1997-1998 season, an outbreak of malaria occurred in the southwestern region. Over a 4-month period, 32 cases (6.2%) of 520 malaria admissions met the World Health Organization criteria for cerebral malaria. The mean patient age was 28 years. Thirteen male and 19 female patients were admitted in coma. The mean duration of coma was 4.3 days; the case fatality rate was 41%. Compared with those who recovered, patients who died had a lower mean admission diastolic blood pressure and hemoglobin level, higher mean blood urea nitrogen and blood glucose levels, and thrombocytopenia. Logistic regression analysis identified treatment with quinine rather than chloroquine to be associated with survival. These findings show the potential of P. falciparum to emerge as chloroquine resistant in previously susceptible areas, resulting in significant morbidity and mortality in spite of sophisticated medical care.
Authors:
A A Alrajhi; I Rahim; M Akood; M Hazmi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  180     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-09     Completed Date:  1999-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1738-41     Citation Subset:  AIM; IM    
Affiliation:
King Faisal Specialist Hospital and Research Centre, Dept. of Medicine, Riyadh 11211, Saudi Arabia. rajhi@kfshrc.edu.sa
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Antimalarials / pharmacology*
Child
Child, Preschool
Chloroquine / pharmacology*
Drug Resistance
Female
Humans
Infant
Malaria, Cerebral / epidemiology*,  parasitology*,  pathology
Male
Middle Aged
Plasmodium falciparum / drug effects*
Saudi Arabia / epidemiology
Chemical
Reg. No./Substance:
0/Antimalarials; 54-05-7/Chloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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