| Chloroquine-resistant Plasmodium falciparum cerebral malaria in a chloroquine-susceptible area. | |
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MedLine Citation:
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PMID: 10515845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chloroquine-resistant Plasmodium falciparum is endemic in many areas. Saudi Arabia was considered to have chloroquine-susceptible P. falciparum. During the 1997-1998 season, an outbreak of malaria occurred in the southwestern region. Over a 4-month period, 32 cases (6.2%) of 520 malaria admissions met the World Health Organization criteria for cerebral malaria. The mean patient age was 28 years. Thirteen male and 19 female patients were admitted in coma. The mean duration of coma was 4.3 days; the case fatality rate was 41%. Compared with those who recovered, patients who died had a lower mean admission diastolic blood pressure and hemoglobin level, higher mean blood urea nitrogen and blood glucose levels, and thrombocytopenia. Logistic regression analysis identified treatment with quinine rather than chloroquine to be associated with survival. These findings show the potential of P. falciparum to emerge as chloroquine resistant in previously susceptible areas, resulting in significant morbidity and mortality in spite of sophisticated medical care. |
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Authors:
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A A Alrajhi; I Rahim; M Akood; M Hazmi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 180 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 1999-12-09 Completed Date: 1999-12-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1738-41 Citation Subset: AIM; IM |
Affiliation:
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King Faisal Specialist Hospital and Research Centre, Dept. of Medicine, Riyadh 11211, Saudi Arabia. rajhi@kfshrc.edu.sa |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Animals Antimalarials / pharmacology* Child Child, Preschool Chloroquine / pharmacology* Drug Resistance Female Humans Infant Malaria, Cerebral / epidemiology*, parasitology*, pathology Male Middle Aged Plasmodium falciparum / drug effects* Saudi Arabia / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 54-05-7/Chloroquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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