Document Detail


Chloroplasts of Arabidopsis are the source and a primary target of a plant-specific programmed cell death signaling pathway.
MedLine Citation:
PMID:  22797473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Enhanced levels of singlet oxygen ((1)O(2)) in chloroplasts trigger programmed cell death. The impact of (1)O(2) production in chloroplasts was monitored first in the conditional fluorescent (flu) mutant of Arabidopsis thaliana that accumulates (1)O(2) upon a dark/light shift. The onset of (1)O(2) production is rapidly followed by a loss of chloroplast integrity that precedes the rupture of the central vacuole and the final collapse of the cell. Inactivation of the two plastid proteins EXECUTER (EX1) and EX2 in the flu mutant abrogates these responses, indicating that disintegration of chloroplasts is due to EX-dependent signaling rather than (1)O(2) directly. In flu seedlings, (1)O(2)-mediated cell death signaling operates as a default pathway that results in seedlings committing suicide. By contrast, EX-dependent signaling in the wild type induces the formation of microlesions without decreasing the viability of seedlings. (1)O(2)-mediated and EX-dependent loss of plastid integrity and cell death in these plants occurs only in cells containing fully developed chloroplasts. Our findings support an as yet unreported signaling role of (1)O(2) in the wild type exposed to mild light stress that invokes photoinhibition of photosystem II without causing photooxidative damage of the plant.
Authors:
Chanhong Kim; Rasa Meskauskiene; Shengrui Zhang; Keun Pyo Lee; Munusamy Lakshmanan Ashok; Karolina Blajecka; Cornelia Herrfurth; Ivo Feussner; Klaus Apel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-07-12
Journal Detail:
Title:  The Plant cell     Volume:  24     ISSN:  1532-298X     ISO Abbreviation:  Plant Cell     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2013-02-14     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9208688     Medline TA:  Plant Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3026-39     Citation Subset:  IM    
Affiliation:
Boyce Thompson Institute for Plant Research, Ithaca, NY 14853-1801, USA.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / physiology*,  radiation effects
Arabidopsis / cytology,  genetics,  physiology*,  radiation effects
Arabidopsis Proteins / genetics,  metabolism
Chloroplast Proteins / genetics,  metabolism
Chloroplasts / physiology*,  radiation effects
Darkness
Gene Expression Regulation, Plant
Light
Mutation
Oxidative Stress / physiology,  radiation effects
Photosystem II Protein Complex / physiology,  radiation effects
Plant Leaves / cytology,  genetics,  physiology,  radiation effects
Seedling / cytology,  genetics,  physiology,  radiation effects
Signal Transduction / physiology*,  radiation effects
Singlet Oxygen / metabolism*
Vacuoles / metabolism,  radiation effects
Grant Support
ID/Acronym/Agency:
R01 GM085036/GM/NIGMS NIH HHS; R01-GM085036/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Chloroplast Proteins; 0/EXECUTER 1 protein, Arabidopsis; 0/EXECUTER 2 protein, Arabidopsis; 0/Photosystem II Protein Complex; 17778-80-2/Singlet Oxygen
Comments/Corrections

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