Document Detail


Chlorophenylpiperazine: a central serotonin agonist causing powerful anorexia in rats.
MedLine Citation:
PMID:  503247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Meta-chlorophenylpiperazine inhibited serotonin and noradrenaline uptake by synaptosomes to the same extent with IC50 of 1.3 x 10(-6) M and 5.8 x 10(-6) M respectively. Dopamine uptake was less affected by meta-chlorophenylpiperazine (IC50 of 2.2 x 10(-5) M). Unlike d-amphetamine and d-fenfluramine, the drug did not significantly increase monoamine release in synaptosomal preparations. On the other hand, metachlorophenylpiperazine showed an IC50 of 620 nM in displacing 3H-5HT binding to brain membranes. Meta-chlorophenylpiperazine produced a dose-dependent reduction of food intake and this effect was prevented by a pretreatment with methergoline, a serotonin antagonist. The effect of metachlorophenylpiperazine was not modified by an intraventricular injection of 6-hydroxydopamine, electrolytic lesions of nucleus medianus raphe or ventral noradrenergic bundle, nor by a pretreatment with penfluridol, propranolol or phentolamine. The data suggest that the decrease of food intake induced by metachlorophenylpiperazine depends on its ability to act as a serotonin agonist is the brain. The specificity of the effects on serotonin suggests that this compound could prove an important tool for studies aimed at elucidating the functional role of serotonin in the central nervous system.
Authors:
R Samanin; T Mennini; A Ferraris; C Bendotti; F Borsini; S Garattini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  308     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1980-01-19     Completed Date:  1980-01-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants*
Brain / ultrastructure
Catecholamines / metabolism*
Dextroamphetamine / pharmacology
Feeding Behavior / drug effects
Female
Fenfluramine / pharmacology
Metergoline / pharmacology
Piperazines / pharmacology*
Rats
Serotonin / physiology*
Synaptosomes / metabolism
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Catecholamines; 0/Piperazines; 17692-51-2/Metergoline; 458-24-2/Fenfluramine; 50-67-9/Serotonin; 51-64-9/Dextroamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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