Document Detail

Chlorogenic acid is poorly absorbed, independently of the food matrix: A Caco-2 cells and rat chronic absorption study.
MedLine Citation:
PMID:  17054098     Owner:  NLM     Status:  MEDLINE    
According to epidemiologic studies, dietary phenolic antioxidants, such as chlorogenic acid (CQA), could prevent coronary heart diseases and some cancers. Coffee is the main source of CQA in the human diet. The aim of this study was to assess the effect of usual coffee consumption conditions, such as the addition of milk, on CQA bioavailability. Interactions between CQA and milk proteins were shown, using an ultrafiltration technique. These interactions proved to be slightly disrupted during an in vitro digestion process. CQA absorption and bioavailability were then studied in vitro using a Caco-2 cell model coupled with an in vitro digestion process, and in vivo, in a chronic supplementation study in which rats were fed daily coffee or coffee and milk for 3 weeks. Both experiments showed that CQA absorption under its native form is weak, but unmodified by the addition of milk proteins, and slightly reduced by the addition of Maillard reaction products. These data show that there are some interactions between coffee phenolics and milk proteins, but these have no significant effect on CQA bioavailability from coffee in the rat. CQA is poorly absorbed under its native form in the body, when ingested in a realistic food matrix.
Coralie Dupas; Agnès Marsset Baglieri; Claire Ordonaud; Daniel Tomé; Marie-Noëlle Maillard
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  50     ISSN:  1613-4125     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-08     Completed Date:  2007-03-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1053-60     Citation Subset:  IM    
UMR 1211 SCALE (ENSIA/INRA/CNAM)--ENSIA, Département Science de l'Aliment, Laboratoire de Chimie des Substances Naturelles: antioxydants, arômes, colorants, Massy, France.
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MeSH Terms
Biological Availability
Caco-2 Cells
Chlorogenic Acid / blood,  pharmacokinetics*
Chromatography, High Pressure Liquid
Coffee / chemistry
Drug Interactions
Intestinal Absorption
Milk Proteins / administration & dosage
Rats, Wistar
Reg. No./Substance:
0/Coffee; 0/Milk Proteins; 327-97-9/Chlorogenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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