Document Detail

Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice.
MedLine Citation:
PMID:  20064576     Owner:  NLM     Status:  MEDLINE    
This study investigated the efficacy of chlorogenic acid on altering body fat in high-fat diet (37% calories from fat) induced-obese mice compared to caffeic acid. Caffeic acid or chlorogenic acid was supplemented with high-fat diet at 0.02% (wt/wt) dose. Both caffeic acid and chlorogenic acid significantly lowered body weight, visceral fat mass and plasma leptin and insulin levels compared to the high-fat control group. They also lowered triglyceride (in plasma, liver and heart) and cholesterol (in plasma, adipose tissue and heart) concentrations. Triglyceride content in adipose tissue was significantly lowered, whereas the plasma adiponectin level was elevated by chlorogenic acid supplementation compared to the high-fat control group. Body weight was significantly correlated with plasma leptin (r=0.894, p<0.01) and insulin (r=0.496, p<0.01) levels, respectively. Caffeic acid and chlorogenic acid significantly inhibited fatty acid synthase, 3-hydroxy-3-methylglutaryl CoA reductase and acyl-CoA:cholesterol acyltransferase activities, while they increased fatty acid beta-oxidation activity and peroxisome proliferator-activated receptors alpha expression in the liver compared to the high-fat group. These results suggest that caffeic acid and chlorogenic acid improve body weight, lipid metabolism and obesity-related hormones levels in high-fat fed mice. Chlorogenic acid seemed to be more potent for body weight reduction and regulation of lipid metabolism than caffeic acid.
Ae-Sim Cho; Seon-Min Jeon; Myung-Joo Kim; Jiyoung Yeo; Kwon-Il Seo; Myung-Sook Choi; Mi-Kyung Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-12
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  937-43     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Department of Nutrition Education, Graduate School of Education, Sunchon National University, Suncheon 540-742, Republic of Korea.
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MeSH Terms
Adiponectin / blood
Adiposity / drug effects
Anti-Obesity Agents*
Antioxidants / pharmacology
Blotting, Western
Body Weight / drug effects
Caffeic Acids / pharmacology
Chlorogenic Acid / pharmacology*
Dietary Fats / adverse effects*
Eating / physiology
Energy Intake / physiology
Insulin / blood
Leptin / blood
Lipid Metabolism / drug effects*
Liver / drug effects,  enzymology
Mice, Inbred ICR
Myocardium / metabolism
Obesity / drug therapy*,  etiology
PPAR alpha / metabolism
Reg. No./Substance:
0/Adiponectin; 0/Anti-Obesity Agents; 0/Antioxidants; 0/Caffeic Acids; 0/Dietary Fats; 0/Leptin; 0/PPAR alpha; 11061-68-0/Insulin; 327-97-9/Chlorogenic Acid; 331-39-5/caffeic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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