Document Detail


Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats.
MedLine Citation:
PMID:  16685206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: Epidemiologic studies indicate that ingestion of vegetables and fruit inhibits the development of cardiovascular disease. Chlorogenic acids are abundant phenolic compounds contained in vegetables and fruits, but the impact of dietary chlorogenic acids on vascular function in hypertension is not known. We therefore examined the effects of 5-caffeoylquinic acid (CQA), a representative chlorogenic acid, on blood pressure and vascular function in age-matched normotensive Wistar-Kyoto rats and spontaneously hypertensive rats. METHODS AND RESULTS: A single ingestion of CQA (30-600 mg/kg) reduced blood pressure in spontaneously hypertensive rats, an effect that was blocked by administration of a nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester. When spontaneously hypertensive rats were fed diets containing 0.5% CQA for 8 weeks (approximately 300 mg/kg per day), the development of hypertension was inhibited compared with the control diet group. CQA ingestion increased urinary excretion of nitric oxide metabolites and decreased urinary excretion of hydrogen peroxide; decreased NADPH-dependent superoxide anion production in the aorta, suggesting that dietary CQA inhibited vascular NADPH oxidase activity; significantly improved acetylcholine-induced endothelium-dependent vasodilation in the aorta; and markedly reduced the degree of immunohistochemical staining for nitrotyrosine and media hypertrophy in aorta sections. In contrast, CQA had no effects in Wistar-Kyoto rats. CONCLUSIONS: Dietary CQA reduces oxidative stress and improves nitric oxide bioavailability by inhibiting excessive production of reactive oxygen species in the vasculature, and leads to the attenuation of endothelial dysfunction, vascular hypertrophy, and hypertension in spontaneously hypertensive rats.
Authors:
Atsushi Suzuki; Naoki Yamamoto; Hiroko Jokura; Masaki Yamamoto; Akihiko Fujii; Ichiro Tokimitsu; Ikuo Saito
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  24     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-10     Completed Date:  2006-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1065-73     Citation Subset:  IM    
Affiliation:
Biological Science Laboratories, Kao Corporation, Tochigi, Japan. suzuki.atsuchi2@kao.co.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / metabolism,  pathology
Blood Pressure / drug effects*
Chlorogenic Acid / pharmacology
Endothelium, Vascular / drug effects*
Hydrogen Peroxide / urine
Immunohistochemistry
Male
NADP / metabolism
NADPH Oxidase / metabolism
Nitrates / urine
Nitric Oxide Synthase Type III / metabolism
Nitrites / urine
Oxidative Stress / drug effects*
Quinic Acid / administration & dosage,  analogs & derivatives*,  pharmacology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Superoxides / metabolism
Tyrosine / analogs & derivatives,  metabolism
Vasodilation / drug effects*
Chemical
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 0/caffeoylquinic acid; 11062-77-4/Superoxides; 327-97-9/Chlorogenic Acid; 3604-79-3/3-nitrotyrosine; 53-59-8/NADP; 55520-40-6/Tyrosine; 77-95-2/Quinic Acid; 7722-84-1/Hydrogen Peroxide; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.6.3.1/NADPH Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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