| Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 16685206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Epidemiologic studies indicate that ingestion of vegetables and fruit inhibits the development of cardiovascular disease. Chlorogenic acids are abundant phenolic compounds contained in vegetables and fruits, but the impact of dietary chlorogenic acids on vascular function in hypertension is not known. We therefore examined the effects of 5-caffeoylquinic acid (CQA), a representative chlorogenic acid, on blood pressure and vascular function in age-matched normotensive Wistar-Kyoto rats and spontaneously hypertensive rats. METHODS AND RESULTS: A single ingestion of CQA (30-600 mg/kg) reduced blood pressure in spontaneously hypertensive rats, an effect that was blocked by administration of a nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester. When spontaneously hypertensive rats were fed diets containing 0.5% CQA for 8 weeks (approximately 300 mg/kg per day), the development of hypertension was inhibited compared with the control diet group. CQA ingestion increased urinary excretion of nitric oxide metabolites and decreased urinary excretion of hydrogen peroxide; decreased NADPH-dependent superoxide anion production in the aorta, suggesting that dietary CQA inhibited vascular NADPH oxidase activity; significantly improved acetylcholine-induced endothelium-dependent vasodilation in the aorta; and markedly reduced the degree of immunohistochemical staining for nitrotyrosine and media hypertrophy in aorta sections. In contrast, CQA had no effects in Wistar-Kyoto rats. CONCLUSIONS: Dietary CQA reduces oxidative stress and improves nitric oxide bioavailability by inhibiting excessive production of reactive oxygen species in the vasculature, and leads to the attenuation of endothelial dysfunction, vascular hypertrophy, and hypertension in spontaneously hypertensive rats. |
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Authors:
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Atsushi Suzuki; Naoki Yamamoto; Hiroko Jokura; Masaki Yamamoto; Akihiko Fujii; Ichiro Tokimitsu; Ikuo Saito |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 24 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-10 Completed Date: 2006-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1065-73 Citation Subset: IM |
Affiliation:
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Biological Science Laboratories, Kao Corporation, Tochigi, Japan. suzuki.atsuchi2@kao.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / metabolism, pathology Blood Pressure / drug effects* Chlorogenic Acid / pharmacology Endothelium, Vascular / drug effects* Hydrogen Peroxide / urine Immunohistochemistry Male NADP / metabolism NADPH Oxidase / metabolism Nitrates / urine Nitric Oxide Synthase Type III / metabolism Nitrites / urine Oxidative Stress / drug effects* Quinic Acid / administration & dosage, analogs & derivatives*, pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY Superoxides / metabolism Tyrosine / analogs & derivatives, metabolism Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 0/Nitrites; 0/caffeoylquinic acid; 11062-77-4/Superoxides; 327-97-9/Chlorogenic Acid; 3604-79-3/3-nitrotyrosine; 53-59-8/NADP; 55520-40-6/Tyrosine; 77-95-2/Quinic Acid; 7722-84-1/Hydrogen Peroxide; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.6.3.1/NADPH Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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