Document Detail

Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats.
MedLine Citation:
PMID:  19786014     Owner:  NLM     Status:  MEDLINE    
This study examined the effects of chlorogenic acid (CGA) on liver fibrosis induced by carbon tetrachloride (CCl(4)) and explored the possible mechanisms of action. Liver fibrosis was induced in male Sprague-Dawley (SD) rats by the injection of 40% CCl(4) subcutaneously twice a week for eight weeks. At the same time, CGA (60 and 30mg/kg) was administered intragastrically once daily to a subset of rats. Upon pathological examination, the CGA-treated rats showed significantly reduced liver damage and symptoms of liver fibrosis. The expression of collagen I and collagen III mRNA was increased markedly by the CCl(4) treatment but this increase was suppressed by CGA. As compared with the CGA-treated group, the expression of bcl-2, vascular endothelial growth factor (VEGF), and transforming growth factor (TGF-beta1) mRNA was increased in CCl(4) group, whereas Bax mRNA expression decreased. The expression of Bax and bcl-2 protein was confirmed by western blotting. Intragastric administration of CGA reduced the protein expression of alpha-smooth muscle actin (alpha-SMA) and glucose-regulated proteins 78 and 94 (GRP78 and GRP94) in rats injured by treatment with CCl(4). Our data indicate that CGA can efficiently inhibit CCl(4)-induced liver fibrosis in rats. Therefore, CGA could be an effective drug for preventing liver fibrosis.
Hongyang Shi; Lei Dong; Yanhua Bai; Juhui Zhao; Yong Zhang; Li Zhang
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Publication Detail:
Type:  Journal Article     Date:  2009-09-26
Journal Detail:
Title:  European journal of pharmacology     Volume:  623     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-28     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  119-24     Citation Subset:  IM    
Department of Gastroenterology, Second Affiliate Hospital of Xian Jiao Tong University, Xian 710004, China.
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MeSH Terms
Actins / metabolism
Carbon Tetrachloride / metabolism,  toxicity
Chlorogenic Acid / metabolism,  therapeutic use*
Collagen Type I / genetics,  metabolism
Collagen Type III / genetics,  metabolism
Gene Expression Regulation / drug effects
HSP70 Heat-Shock Proteins / metabolism
Heat-Shock Proteins / metabolism
Liver / pathology,  physiopathology*
Liver Cirrhosis / chemically induced,  metabolism,  prevention & control*
Membrane Proteins / metabolism
Protective Agents / metabolism,  therapeutic use*
Proto-Oncogene Proteins c-bcl-2 / genetics,  metabolism
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Transforming Growth Factor beta1 / genetics,  metabolism
Vascular Endothelial Growth Factors / genetics,  metabolism
Reg. No./Substance:
0/Actins; 0/Collagen Type I; 0/Collagen Type III; 0/HSP70 Heat-Shock Proteins; 0/Heat-Shock Proteins; 0/Hspa5 protein, rat; 0/Membrane Proteins; 0/Protective Agents; 0/Proto-Oncogene Proteins c-bcl-2; 0/RNA, Messenger; 0/Transforming Growth Factor beta1; 0/Vascular Endothelial Growth Factors; 0/glucose-regulated proteins; 0/smooth muscle actin, rat; 327-97-9/Chlorogenic Acid; 56-23-5/Carbon Tetrachloride

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