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Chloride Balance in Preterm Infants during the First Week of Life.
MedLine Citation:
PMID:  22505945     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Objective. To describe the chloride balance in infants born 25-32-week gestation, analyze the association of chloride changes with hydroelectrolytic status and their relationship with perinatal conditions, morbidities, and neurological outcome. Methods. For 7 days after birth, sodium and chloride balance, plasma potassium, phosphate, and total carbon dioxide (tCO(2)) were prospectively determined and strong ion difference (SID) calculated. Three multivariate regression analyses were performed to identify factors associated with high plasma chloride concentration, low SID, and low tCO(2). Results. 107 infants were studied. Plasma chloride concentration was significantly positively associated with plasma sodium concentration. Higher plasma chloride and lower SID were significantly associated with lower plasma tCO(2). Chloride intake was the main independent factor associated with high plasma chloride, low SID, and low plasma tCO(2), with lesser contribution of sodium intake and low gestational age (GA). Also, patent ductus arteriosus and birth weight loss were independent factors affecting plasma chloride and SID. Neither high chloride levels nor low SID were associated to impaired neurological outcome. Conclusions. In preterm infants, chloride balance is influenced by GA and by interrelationship between sodium and chloride intake. High chloride levels are associated with metabolic acidosis but not related to increased risk of impaired neurological outcome.
Authors:
Silvia Iacobelli; Elsa Kermorvant-Duchemin; Francesco Bonsante; Alexandre Lapillonne; Jean-Bernard Gouyon
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Publication Detail:
Type:  Journal Article     Date:  2012-03-08
Journal Detail:
Title:  International journal of pediatrics     Volume:  2012     ISSN:  1687-9759     ISO Abbreviation:  Int J Pediatr     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-08-23     Revised Date:  2013-03-01    
Medline Journal Info:
Nlm Unique ID:  101517077     Medline TA:  Int J Pediatr     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  931597     Citation Subset:  -    
Affiliation:
Neonatology and NICU, GHSR, CHR, BP 350, 97448 Saint Pierre Cedex, Réunion, France.
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