Document Detail

Chlorhexidine--pharmacology and clinical applications.
MedLine Citation:
PMID:  18714617     Owner:  NLM     Status:  MEDLINE    
Chlorhexidine is a widely used skin antisepsis preparation and is an ingredient in toothpaste and mouthwash. It is an especially effective antiseptic when combined with alcohol. Its antimicrobial effects persist because it is binds strongly to proteins in the skin and mucosa, making it an effective antiseptic ingredient for handwashing, skin preparation for surgery and the placement of intravascular access. Catheters impregnated with chlorhexidine and antimicrobial agents can reduce the incidence of catheter-related bloodstream infections. Contact dermatitis related to chlorhexidine is not common in health care workers. The incidence of contact dermatitis to chlorhexidine in atopic patients is approximately 2.5 to 5.4%. Acute hypersensitivity reactions to chlorhexidine are often not recognised and therefore may be underreported. This review discusses the pharmacology, microbiology, clinical applications and adverse effects of chlorhexidine.
K-S Lim; P C A Kam
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  36     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  502-12     Citation Subset:  IM    
Department of Anaesthetics, University of Sydney, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
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MeSH Terms
Anti-Infective Agents, Local / adverse effects,  pharmacology*
Bacteremia / microbiology,  prevention & control
Catheterization / adverse effects,  methods
Chlorhexidine / adverse effects,  pharmacology*
Cross Infection / prevention & control
Dermatomycoses / prevention & control
Drug Hypersensitivity / etiology*
Equipment Contamination / prevention & control
Handwashing / methods
Iodine / pharmacology
Oral Hygiene / methods
Treatment Outcome
Reg. No./Substance:
0/Anti-Infective Agents, Local; 55-56-1/Chlorhexidine; 7553-56-2/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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