| Chlorhexidine--pharmacology and clinical applications. | |
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MedLine Citation:
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PMID: 18714617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chlorhexidine is a widely used skin antisepsis preparation and is an ingredient in toothpaste and mouthwash. It is an especially effective antiseptic when combined with alcohol. Its antimicrobial effects persist because it is binds strongly to proteins in the skin and mucosa, making it an effective antiseptic ingredient for handwashing, skin preparation for surgery and the placement of intravascular access. Catheters impregnated with chlorhexidine and antimicrobial agents can reduce the incidence of catheter-related bloodstream infections. Contact dermatitis related to chlorhexidine is not common in health care workers. The incidence of contact dermatitis to chlorhexidine in atopic patients is approximately 2.5 to 5.4%. Acute hypersensitivity reactions to chlorhexidine are often not recognised and therefore may be underreported. This review discusses the pharmacology, microbiology, clinical applications and adverse effects of chlorhexidine. |
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Authors:
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K-S Lim; P C A Kam |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anaesthesia and intensive care Volume: 36 ISSN: 0310-057X ISO Abbreviation: Anaesth Intensive Care Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-08-21 Completed Date: 2008-12-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0342017 Medline TA: Anaesth Intensive Care Country: Australia |
Other Details:
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Languages: eng Pagination: 502-12 Citation Subset: IM |
Affiliation:
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Department of Anaesthetics, University of Sydney, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents, Local
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adverse effects,
pharmacology* Bacteremia / microbiology, prevention & control Catheterization / adverse effects, methods Chlorhexidine / adverse effects, pharmacology* Cross Infection / prevention & control Dermatomycoses / prevention & control Drug Hypersensitivity / etiology* Equipment Contamination / prevention & control Handwashing / methods Humans Iodine / pharmacology Oral Hygiene / methods Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 55-56-1/Chlorhexidine; 7553-56-2/Iodine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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