Document Detail

Chlorhexidine-impregnated dressing for prevention of colonization of central venous catheters in infants and children: a randomized controlled study.
MedLine Citation:
PMID:  16094219     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Infections of short term, nontunneled, intravascular catheters are often caused by migration of organisms from the insertion site. The aim of this study was to evaluate the effectiveness and safety of a chlorhexidine gluconate-impregnated dressing for the reduction of central venous catheter (CVC) colonization and CVC-associated bloodstream infections in infants and children after cardiac surgery.
METHODS: This prospective, randomized, controlled study was conducted in the pediatric cardiac intensive care unit of a tertiary care pediatric medical center. Patients 0-18 years of age who were admitted to the pediatric cardiac intensive care unit during a 14-month period and required a CVC for >48 hours were randomized to receive a transparent polyurethane insertion site dressing (control group) or a chlorhexidine gluconate-impregnated sponge (Biopatch) dressing covered by a transparent polyurethane dressing (study group). The main outcome measures were rates of bacterial colonization, rates of CVC-associated bloodstream infections and adverse events.
RESULTS: Seventy-one patients were randomized to the control group and 74 to the study group. There were no significant between group differences in age, sex, Pediatric Risk of Mortality score or cardiac severity score. CVC colonization occurred in 21 control patients (29%) and 11 (14.8%) study patients (P = 0.0446; relative risk, 0.6166; 95% confidence interval, 0.3716-1.023). Bloodstream infection occurred in 3 patients (4.2%) in the control group and 4 patients (5.4%) in the study group. Local redness was noted in 1 control patient and 4 study group patients.
CONCLUSIONS: The chlorhexidine gluconate-impregnated sponge is safe and significantly reduces the rates of CVC colonization in infants and children after cardiac surgery.
Itzhak Levy; Jacob Katz; Ester Solter; Zmira Samra; Bernardo Vidne; Einat Birk; Shai Ashkenazi; Ovadia Dagan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  24     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-11     Completed Date:  2005-10-19     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  676-9     Citation Subset:  IM    
Department of Pediatric Infectious Diseases, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel.
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MeSH Terms
Administration, Cutaneous
Anti-Infective Agents, Local / administration & dosage*
Catheterization, Central Venous / adverse effects*
Catheters, Indwelling / adverse effects,  microbiology*
Child, Preschool
Chlorhexidine / administration & dosage,  analogs & derivatives*
Equipment Contamination / prevention & control*
Prospective Studies
Reg. No./Substance:
0/Anti-Infective Agents, Local; 55-56-1/Chlorhexidine; MOR84MUD8E/chlorhexidine gluconate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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