Document Detail


Chloramphenicol 1. Hazards of use and the current regulatory environment.
MedLine Citation:
PMID:  2018448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chloramphenicol is a broad-spectrum antibiotic which has enjoyed extensive use in both medical and veterinary practice. Shortly after its introduction in the late 1940s, the use of chloramphenicol was associated with the induction of an idiosyncratic form of aplastic anaemia in man. This rare and unpredictable adverse effect has since been associated not only with systemic use but with topical applications, as well as occupational exposure. Recognition of the small risk of a potentially fatal adverse reaction, together with the risk of selection of chloramphenicol-resistant pathogens, has led to restrictions on the veterinary uses of chloramphenicol. In Australia at present, the use of chloramphenicol is only permitted in small animals. Its use is specifically prohibited in food-producing animals, including horses.
Authors:
S W Page
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Australian veterinary journal     Volume:  68     ISSN:  0005-0423     ISO Abbreviation:  Aust. Vet. J.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-05-22     Completed Date:  1991-05-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370616     Medline TA:  Aust Vet J     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  1-2     Citation Subset:  IM    
Affiliation:
Australian Veterinary Association Subcommittee on Therapeutics, Artarmon, New South Wales.
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MeSH Terms
Descriptor/Qualifier:
Agricultural Workers' Diseases / chemically induced
Anemia, Aplastic / chemically induced*
Animals
Animals, Domestic*
Australia
Chloramphenicol / adverse effects*
Drug Residues / adverse effects*
Great Britain
Humans
Legislation, Drug*
United States
Chemical
Reg. No./Substance:
56-75-7/Chloramphenicol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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