Document Detail

Chlorambucil-induced myoclonus in a cat with lymphoma.
MedLine Citation:
PMID:  12755202     Owner:  NLM     Status:  MEDLINE    
Chlorambucil is an alkylating agent commonly used in veterinary oncology for conditions including lymphoma. Chlorambucil neurotoxicity has been well recognized in human patients. Onsets of central nervous system signs, such as myoclonus, tremors, muscular twitching, agitation, and tonic-clonic seizures, have been reported in humans and laboratory animals treated with chlorambucil. This case of a cat with intestinal lymphoma represents the first veterinary patient reported to have chlorambucil-induced neurotoxicity. Neurotoxicity should be considered a potential side effect of chlorambucil therapy in veterinary patients.
Noémi Benitah; Louis-Philippe de Lorimier; Michele Gaspar; Barbara E Kitchell
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Animal Hospital Association     Volume:  39     ISSN:  0587-2871     ISO Abbreviation:  J Am Anim Hosp Assoc     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-05-20     Completed Date:  2003-06-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0415027     Medline TA:  J Am Anim Hosp Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
Department of Veterinary Clinical Medicine, Veterinary Teaching Hospital, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, Urbana, Illinois 61802, USA.
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MeSH Terms
Antineoplastic Agents, Alkylating / adverse effects*
Cat Diseases / diagnosis*,  pathology
Chlorambucil / adverse effects*
Diagnosis, Differential
Intestinal Neoplasms / drug therapy,  veterinary*
Intestine, Small
Lymphoma / drug therapy,  veterinary*
Myoclonus / chemically induced,  diagnosis*
Reg. No./Substance:
0/Antineoplastic Agents, Alkylating; 305-03-3/Chlorambucil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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