Document Detail

Chlamydia trachomatis infections in neonates and young children.
MedLine Citation:
PMID:  16210104     Owner:  NLM     Status:  MEDLINE    
In 1911, Lindner and colleagues identified intracytoplasmic inclusions in infants with a nongonococcal form of ophthalmia neonatorum called inclusion conjunctivitis of the newborn (ICN). Mothers of affected infants were found to have inclusions in their cervical epithelial cells, fathers of such infants had inclusions in their urethral cells, and the epidemiology of sexually transmitted chlamydial infections was revealed. Fifty years later, chlamydial isolation procedures were developed, and studies again demonstrated Chlamydia trachomatis as an etiology of ICN and the female birth canal as the reservoir. In the late 1970s, a report by Beem and Saxon described respiratory tract colonization and a distinct pneumonia syndrome in infected infants. Genital chlamydial infection is recognized as the world's most common sexually transmitted disease, with estimates of greater than 4 million new infections occurring annually in the United States. Although most C. trachomatis infections in men and women are asymptomatic, infection can lead to severe reproductive complications in women. The high prevalence in women of child-bearing age results in exposure of an estimated 100,000 neonates in the United States annually. Many of these infants develop conjunctivitis, pneumonia, or both in the first few months of life. Clinical features, diagnosis, treatment, and approaches to prevention of conjunctivitis and pneumonia in the newborn and young infant are reviewed here. Appropriate testing for chlamydial infection in a pediatric victim of sexual assault and the implications of identifying C. trachomatis in suspected cases of childhood sexual abuse also are reviewed.
Toni Darville
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in pediatric infectious diseases     Volume:  16     ISSN:  1045-1870     ISO Abbreviation:  Semin Pediatr Infect Dis     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-07     Completed Date:  2005-12-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9008093     Medline TA:  Semin Pediatr Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  235-44     Citation Subset:  IM    
Division of Pediatric Infectious Diseases, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Child, Preschool
Chlamydia Infections* / drug therapy,  epidemiology,  transmission
Chlamydia trachomatis / growth & development*
Conjunctivitis, Inclusion* / epidemiology,  microbiology,  transmission
Infant, Newborn
Infectious Disease Transmission, Vertical
Pneumonia, Bacterial* / drug therapy,  epidemiology,  transmission
Pregnancy Complications, Infectious / drug therapy,  epidemiology,  pathology
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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