Document Detail

Chlamydia trachomatis in subfertile couples undergoing an in vitro fertilization program: a prospective study.
MedLine Citation:
PMID:  16701936     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The objectives were to estimate the prevalence of Chlamydia trachomatis infection in subfertile couples and to study the relationship between markers of C. trachomatis infection and male infertility as well as pregnancy rates after in vitro fertilization (IVF). STUDY DESIGN: All consecutive couples consulting for infertility and IVF in Pellegrin Hospital were screened for C. trachomatis by direct (PCR test) and serological methods. RESULTS: Two hundred and seventy-seven couples were included in the study (mean age in years: 35 for men, 32 for women; mean duration of infertility: 4 years). The most frequent indication for IVF was tubal factor in 33%, endometriosis in 6%, dysovarian function in 12%, male infertility in 36% and others in 13%. C. trachomatis PCR was positive in 1.2% of men, 95% confidence interval (CI95%): (0.2%; 3.3%) and in 2.7% of women, CI95%: (1.1%; 5.5%). When combining all chlamydial markers, 17.3% of men, CI95%: (12.7%; 22.8%) and 20.4% of women, CI95%: (15.6%; 25.9%) had at least one positive marker. The presence of positive markers was not associated with altered semen characteristics. Couples with positive markers had a pregnancy rate of 23.1% (12 out of 52) compared with 20.2% (24 out of 119) among those with negative markers. CONCLUSION: In this population, the presence of past or current C. trachomatis infection was associated with neither semen characteristics nor outcome of IVF in subfertile couples.
Bertille de Barbeyrac; Aline Papaxanthos-Roche; Claudine Mathieu; Christine Germain; Jean Luc Brun; Monique Gachet; Guy Mayer; Christiane Bébéar; Geneviève Chene; Claude Hocké
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-15
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  129     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  46-53     Citation Subset:  IM    
Service de Bactériologie, Hôpital Pellegrin, Centre Hospitalier Universitaire, Bordeaux, France.
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MeSH Terms
Chlamydia Infections / microbiology*
Chlamydia trachomatis / immunology*
Fertilization in Vitro*
Infertility, Male / microbiology*
Pregnancy Outcome
Prospective Studies
Semen / microbiology,  physiology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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