| Chlamydia trachomatis as a cause of neonatal conjunctivitis in Dutch infants. | |
| | |
MedLine Citation:
|
PMID: 18245405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Chlamydia trachomatis is the most common sexually transmitted pathogen in adults, which at delivery may be transmitted from mother to child and cause conjunctivitis and pneumonia. In The Netherlands, prenatal chlamydial screening and treatment of pregnant women is not routine practice. The contribution of C. trachomatis to neonatal ophthalmic disease has not been studied in The Netherlands and remains unclear. METHODS: At the Sophia Children's Hospital and Rotterdam Eye Hospital, 2 cohorts of infants <3 months of age presenting with conjunctivitis were studied, 1 retrospectively (July 1996 to July 2001) and 1 prospectively (September 2001 to September 2002). Laboratory diagnosis was based on bacterial culture and polymerase chain reaction for C. trachomatis. RESULTS: C. trachomatis was detected in 27 (64%) of 42 retrospectively studied infants and 14 (61%) of 23 prospectively studied infants. Mucopurulent discharge was present in 35 (95%) of 37, swelling of the eyes in 27 (73%) of 37, conjunctival erythema in 24 (65%) of 37, respiratory symptoms in 14 (38%) of 37, and feeding problems in 5 (14%) of 37 infants respectively. Before microbiological diagnosis, general practitioners prescribed antichlamydial antibiotics locally to 5 (12%) of 41 and systemically to 4 (10%) of 41 infants who tested positive for chlamydia, and ophthalmologists prescribed to 21 (51%) of 41 and 7 (17%) of 41, respectively. CONCLUSIONS: C. trachomatis was the major cause of bacterial conjunctivitis in this population. Clinically, differentiation from other pathogens was not possible. Many infants who tested positive for chlamydia did not receive appropriate antibiotic treatment. |
| | |
Authors:
|
Ingrid G I J G Rours; Margaret R Hammerschlag; Alewijn Ott; Tjeerd J T H N De Faber; Henri A Verbrugh; Ronald de Groot; Roel P Verkooyen |
Related Documents
:
|
6201365 - Lactoferrin in relation to acute phase proteins in sera from newborn infants with sever... 19820425 - Detection of cytomegalovirus dna in dried blood spots of minnesota infants who do not p... 7885315 - Evaluation of congenital syphilis surveillance system--new jersey, 1993. 9924555 - The early natural history of vertically transmitted hiv-1 infection in african children... 11807085 - Fimz is a molecular link between sticking and swimming in salmonella enterica serovar t... 10260925 - A socio-medical study of infant mortality among disadvantaged blacks. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pediatrics Volume: 121 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-02-04 Completed Date: 2008-02-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
|
Languages: eng Pagination: e321-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatrics, Erasmus Medical Centre, Sophia Children's Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands. rours123@planet.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Anti-Bacterial Agents / therapeutic use Chlamydia trachomatis / isolation & purification* Conjunctivitis, Inclusion / diagnosis, drug therapy, epidemiology* Female Humans Infant, Newborn Male Netherlands / epidemiology Prospective Studies Retrospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Atomoxetine for the treatment of attention-deficit/hyperactivity disorder and oppositional defiant d...
Next Document: Analgesic properties of oral sucrose during routine immunizations at 2 and 4 months of age.