Document Detail


Chlamydia trachomatis antibody detection and diagnosis of reactive arthritis.
MedLine Citation:
PMID:  9825743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate whether determining the presence of serum or synovial fluid (SF) IgG and IgA of anti-Chlamydia antibodies with two recent commercially available enzyme-linked immunosorbent assays (ELISA) using synthetic peptides or recombinant antigen could be helpful to detect possible Chlamydia trachomatis (CT)-involved disease in rheumatological patients without evidence of urogenital CT infection. METHODS: The prevalence of such antibodies was determined in samples from patients with well-defined disease, i.e. CT sexually acquired arthritis and from patients with other inflammatory arthropathies unrelated to CT. RESULTS: When considering IgG and/or IgA anti-MOMP or anti-LPS antibodies, a sensitivity of 100% was obtained for serum and SF samples, but with a low specificity. A sensitivity and a specificity equal or close to 80% were observed for the SF IgG anti-MOMP antibodies. CONCLUSION: Clinically, the most appropriate determination was the SF IgG anti-MOMP antibodies. This commercially available ELISA test could be useful for the diagnosis of probable CT reactive arthritis.
Authors:
S Bas; T L Vischer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  37     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-03     Completed Date:  1998-12-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1054-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, University Hospital, Geneva, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antibodies, Bacterial / analysis*
Antigens, Bacterial / immunology
Arthritis, Reactive / diagnosis*,  immunology,  microbiology
Bacterial Outer Membrane Proteins / immunology
Chlamydia Infections / diagnosis*,  immunology,  microbiology
Chlamydia trachomatis / immunology*
Enzyme-Linked Immunosorbent Assay
Evaluation Studies as Topic
Female
Humans
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Male
Middle Aged
Porins*
Predictive Value of Tests
Recombinant Proteins
Synovial Fluid / immunology,  microbiology
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Bacterial Outer Membrane Proteins; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Porins; 0/Recombinant Proteins; 146409-23-6/omp1 protein, Chlamydia trachomatis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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