Document Detail


A Chlamydia pneumoniae component that induces macrophage foam cell formation is chlamydial lipopolysaccharide.
MedLine Citation:
PMID:  9784505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chlamydia pneumoniae infection is associated with atherosclerotic heart and vessel disease, but a causal relationship between this pathogen and the disease process has not been established. Recently, it was reported that C. pneumoniae induces human macrophage foam cell formation, a key event in early atheroma development, suggesting a role for the organism in atherogenesis. This study further examines C. pneumoniae-induced foam cell formation in the murine macrophage cell line RAW-264.7. Infected RAW cells accumulated cholesteryl esters when cultured in the presence of low-density lipoprotein in a manner similar to that described for human macrophages. Exposure of C. pneumoniae elementary bodies to periodate, but not elevated temperatures, inhibited cholesteryl ester accumulation, suggesting a role for chlamydial lipopolysaccharide (cLPS) in macrophage foam cell formation. Purified cLPS was found to be sufficient to induce cholesteryl ester accumulation and foam cell formation. Furthermore, the LPS antagonist lipid X inhibited C. pneumoniae and cLPS-induced lipid uptake. These data indicate that cLPS is a C. pneumoniae component that induces macrophage foam cell formation and suggest that infected macrophages chronically exposed to cLPS may accumulate excess cholesterol to contribute to atheroma development.
Authors:
M V Kalayoglu; G I Byrne
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  66     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-11-23     Completed Date:  1998-11-23     Revised Date:  2014-03-20    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5067-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteriosclerosis / microbiology
Cell Differentiation / drug effects
Cell Line
Chlamydophila pneumoniae / chemistry,  physiology*
Cholesterol Esters / metabolism
Foam Cells / drug effects,  microbiology*,  pathology
Glycolipids / pharmacology
Growth Inhibitors / pharmacology
Lipopolysaccharides / pharmacology*
Mice
Periodic Acid / pharmacology
Temperature
Grant Support
ID/Acronym/Agency:
AI 19782/AI/NIAID NIH HHS; AI 34617/AI/NIAID NIH HHS; P01 AI034617/AI/NIAID NIH HHS; R01 AI019782/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Glycolipids; 0/Growth Inhibitors; 0/Lipopolysaccharides; 10450-60-9/Periodic Acid; 7790-28-5/metaperiodate; 86559-73-1/lipid X
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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