Document Detail

Chlamydia pneumoniae but not cytomegalovirus antibodies are associated with future risk of stroke and cardiovascular disease: a prospective study in middle-aged to elderly men with treated hypertension.
MedLine Citation:
PMID:  9933263     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Several cross-sectional and prospective studies have indicated that high titers of antibodies to Chlamydia pneumoniae and cytomegalovirus (CMV) are associated with coronary heart disease. The aim of the present study was to examine whether elevated titers of antibodies to these pathogens are predictive of not only coronary but also cerebrovascular disease. METHODS: Serum titers of antibodies to C pneumoniae (IgM, IgG, IgA, IgG immune complex) and CMV (IgG) were determined at baseline (n=130) and after 3.5 years (n=111) in a total sample of 152 men. All individuals had treated hypertension and at least 1 additional risk factor for cardiovascular disease (hypercholesterolemia, smoking, or diabetes mellitus) and constituted 93% of a randomly selected subgroup (n=164) of patients participating in a multiple risk factor intervention study. RESULTS: Elevations of any or both of the IgA or IgG titers to C pneumoniae at entry or after 3.5 years were found in 84 cases (55%). Of those with high titers at entry, 97% remained high at the 3.5 year reexamination. After 6.5 years of follow-up, high titers to C pneumoniae at entry were associated with an increased risk for future stroke (relative risk [RR], 8.58; P=0.043; 95% CI, 1.07 to 68.82) and for any cardiovascular event (RR, 2.69; P=0.042; 95% CI, 1.04 to 6.97). A high serum titer of antibodies to CMV was found in 125 cases (85%), and this was not associated with an increased risk of future cardiovascular events. CONCLUSIONS: Seropositivity for C pneumoniae, but not for CMV, was associated with an increased risk for future cardiovascular disease and, in particular, stroke.
B Fagerberg; J Gnarpe; H Gnarpe; S Agewall; J Wikstrand
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  30     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-01     Completed Date:  1999-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
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MeSH Terms
Antibodies, Bacterial / analysis*
Antibodies, Viral / analysis*
Antihypertensive Agents / therapeutic use
Biological Markers / blood
Cerebrovascular Disorders / diagnosis,  immunology,  microbiology*
Chlamydophila pneumoniae / immunology*
Coronary Disease / diagnosis,  immunology,  microbiology*
Cross-Sectional Studies
Cytomegalovirus / immunology*
Follow-Up Studies
Hypertension / complications,  drug therapy*
Immunoglobulin A / immunology
Immunoglobulin G / immunology
Middle Aged
Predictive Value of Tests
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antibodies, Viral; 0/Antihypertensive Agents; 0/Biological Markers; 0/Immunoglobulin A; 0/Immunoglobulin G

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