Document Detail

Chlamydia pneumoniae, but not Bartonella quintana, is associated with coronary heart disease: results of a French case-control study.
MedLine Citation:
PMID:  12667243     Owner:  NLM     Status:  MEDLINE    
Serologic cross-reactivity has been demonstrated between Bartonella quintana and Chlamydia pneumoniae. Therefore, the association between antibodies to C. pneumoniae and coronary heart disease (CHD) as described in the literature may be due to antibodies cross-reacting with B. quintana. To investigate this hypothesis, we evaluated, in a case-control study, the prevalence of C. pneumoniae and B. quintana antibodies among 296 cases with angiographically significant artery lesions and 170 controls without angiographically demonstrable coronary artery disease. The prevalence of C. pneumoniae antibodies was higher among cases than among controls: 69% versus 49% (P < 0.001; OR 1.39; 95% CI (1.55; 3.52)). Multiple logistic regression demonstrated that C. pneumoniae seropositivity is an independent risk factor for CHD (adjusted OR 2.31; 95% CI (1.49; 3.60)). No statistically significant association was demonstrated between B. quintana seropositivity and CHD. Antibodies to both C. pneumoniae and B. quintana were found in nine subjects (seven cases and two controls), suggesting co-infection rather than cross-reactivity.
S Badiaga; F Paganelli; P Parola; M Beghin; K Barrau; F Eb; P Brouqui
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  9     ISSN:  1198-743X     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-01     Completed Date:  2003-06-03     Revised Date:  2006-11-07    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  315-8     Citation Subset:  IM    
Service des Maladies Infectieuses et Tropicales and Service de Cardiologie, Hôpital Nord, Marseille, France.
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MeSH Terms
Bartonella quintana / isolation & purification*
Case-Control Studies
Chlamydophila Infections / diagnosis,  epidemiology,  microbiology*
Chlamydophila pneumoniae / isolation & purification*
Coronary Disease / diagnosis,  epidemiology,  microbiology*
France / epidemiology
Risk Factors
Seroepidemiologic Studies
Trench Fever / diagnosis,  epidemiology,  microbiology

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