| Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in peritoneal dialysis patients. | |
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MedLine Citation:
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PMID: 11216566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the present study was to examine the association between infection with Chlamydia pneumoniae and symptomatic atherosclerosis in peritoneal dialysis (PD) patients. DESIGN: Cross-sectional study. SETTING: Peritoneal Dialysis Unit of Kingston General Hospital. PATIENTS: Fifty-five prevalent PD patients. OUTCOME MEASURES: (1) Infection with C. pneumoniae diagnosed by detection of DNA in peripheral blood mononuclear cells (PBMCs) using polymerase chain reaction. (2) Symptomatic atherosclerosis involving the coronary, cerebral, or peripheral circulation. RESULTS: The DNA of C. pneumoniae was detected in PBMCs in 33 patients (60.0%). Atherosclerosis was present in 16 of 33 (48%) PBMC C. pneumoniae DNA-positive patients, and in 10 of 22 (45%) PBMC C. pneumoniae DNA-negative patients (p = 0.83). Using multiple logistic regression and controlling for a number of known cardiovascular risk factors, PBMC C. pneumoniae DNA status was not predictive of atherosclerosis. The only significant independent predictors of atherosclerosis were diabetes and age. CONCLUSIONS: In prevalent PD patients, a high prevalence of symptomatic atherosclerosis and of Chlamydia pneumoniae DNA in PBMCs were seen; however, the results of the present study do not support the presence of an association between infection with C. pneumoniae and atherosclerosis. |
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Authors:
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E A Iliescu; M F Fiebig; A R Morton; P Sankar-Mistry |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis Volume: 20 ISSN: 0896-8608 ISO Abbreviation: Perit Dial Int Publication Date: 2000 Nov-Dec |
Date Detail:
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Created Date: 2001-02-16 Completed Date: 2001-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904033 Medline TA: Perit Dial Int Country: Canada |
Other Details:
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Languages: eng Pagination: 722-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Queen's University, Kingston, Ontario, Canada. eai1@post.queensu.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteriosclerosis
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complications* Chlamydophila Infections / complications*, diagnosis Chlamydophila pneumoniae / genetics* Cross-Sectional Studies DNA, Fungal / analysis* Female Humans Kidney Failure, Chronic / complications*, therapy Leukocytes, Mononuclear / chemistry* Male Middle Aged Peritoneal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Fungal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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