Document Detail

Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in peritoneal dialysis patients.
MedLine Citation:
PMID:  11216566     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the present study was to examine the association between infection with Chlamydia pneumoniae and symptomatic atherosclerosis in peritoneal dialysis (PD) patients. DESIGN: Cross-sectional study. SETTING: Peritoneal Dialysis Unit of Kingston General Hospital. PATIENTS: Fifty-five prevalent PD patients. OUTCOME MEASURES: (1) Infection with C. pneumoniae diagnosed by detection of DNA in peripheral blood mononuclear cells (PBMCs) using polymerase chain reaction. (2) Symptomatic atherosclerosis involving the coronary, cerebral, or peripheral circulation. RESULTS: The DNA of C. pneumoniae was detected in PBMCs in 33 patients (60.0%). Atherosclerosis was present in 16 of 33 (48%) PBMC C. pneumoniae DNA-positive patients, and in 10 of 22 (45%) PBMC C. pneumoniae DNA-negative patients (p = 0.83). Using multiple logistic regression and controlling for a number of known cardiovascular risk factors, PBMC C. pneumoniae DNA status was not predictive of atherosclerosis. The only significant independent predictors of atherosclerosis were diabetes and age. CONCLUSIONS: In prevalent PD patients, a high prevalence of symptomatic atherosclerosis and of Chlamydia pneumoniae DNA in PBMCs were seen; however, the results of the present study do not support the presence of an association between infection with C. pneumoniae and atherosclerosis.
E A Iliescu; M F Fiebig; A R Morton; P Sankar-Mistry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  20     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-02-16     Completed Date:  2001-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  722-6     Citation Subset:  IM    
Department of Medicine, Queen's University, Kingston, Ontario, Canada.
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MeSH Terms
Arteriosclerosis / complications*
Chlamydophila Infections / complications*,  diagnosis
Chlamydophila pneumoniae / genetics*
Cross-Sectional Studies
DNA, Fungal / analysis*
Kidney Failure, Chronic / complications*,  therapy
Leukocytes, Mononuclear / chemistry*
Middle Aged
Peritoneal Dialysis*
Reg. No./Substance:
0/DNA, Fungal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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