| Chk1 activation and the nuclear/cytoplasmic ratio. | |
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MedLine Citation:
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PMID: 15296709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ATR and Chk1 are important components of a cell cycle checkpoint pathway. In this issue of Developmental Cell, Conn et al. shed a novel light on the molecular mechanism of Chk1 activation and raise the possibility of a developmental checkpoint that regulates Chk1 in response to the nuclear/cytoplasmic ratio. |
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Authors:
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Jennifer Pogoriler; Wei Du |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Developmental cell Volume: 7 ISSN: 1534-5807 ISO Abbreviation: Dev. Cell Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-06 Completed Date: 2004-09-07 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 101120028 Medline TA: Dev Cell Country: United States |
Other Details:
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Languages: eng Pagination: 147-8 Citation Subset: IM |
Affiliation:
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Ben May Institute for Cancer Research, Committee on Cancer Biology, University of Chicago, 924 East 57th Street, IL 60637 USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle Cell Cycle Proteins / metabolism* Cell Nucleus / metabolism* Cytoplasm / metabolism* Enzyme Activation Gene Expression Regulation, Developmental* Models, Biological Protein Kinases / metabolism* Protein-Serine-Threonine Kinases / metabolism* cdc25 Phosphatases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; EC 2.7.-/Protein Kinases; EC 2.7.11.1/Checkpoint kinase 1; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 3.1.3.48/cdc25 Phosphatases |
| Comments/Corrections | |
Comment On:
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Dev Cell. 2004 Aug;7(2):275-81
[PMID:
15296723
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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