Document Detail


Chitotriosidase and YKL-40 in normal and pre-eclamptic pregnancies.
MedLine Citation:
PMID:  18054022     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare macrophage activation in normal and pre-eclamptic pregnancies by determining YKL-40 concentration and chitotriosidase activity in maternal and cord serum. METHODS: In this prospective case-control study samples of maternal peripheral blood and umbilical venous blood were collected from 28 pre-eclamptic and 24 normotensive pregnant women and their newborns. YKL-40 concentration and chitotriosidase activity were determined by enzyme-linked immunoassay and fluorometry, respectively. RESULTS: Chitotriosidase activity in maternal and cord serum and YKL-40 concentration in cord serum were significantly higher in pre-eclamptic pregnancies (P<0.001), but there was no significant difference in maternal serum levels of YKL-40 between the case and control groups (P>0.05). There was a significant positive correlation between diastolic blood pressure and (1) chitotriosidase activity in both maternal and cord serum and (2) cord serum concentration of YKL-40 (r=0.61, r=0.84, and r=0.58, respectively). CONCLUSION: This study may be the first to demonstrate maternal and fetal macrophage activation in pre-eclampsia.
Authors:
Riza Madazli; Mine Kucur; Altay Gezer; Ferruh Isman; Berk Bulut
Publication Detail:
Type:  Journal Article     Date:  2007-12-03
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  100     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-07-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, Istanbul, Turkey. madazli@superonline.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Blood Pressure / physiology
Case-Control Studies
Female
Fetal Blood / chemistry*
Glycoproteins / blood*
Hexosaminidases / blood*
Humans
Infant, Newborn
Lectins
Macrophage Activation / physiology*
Pre-Eclampsia / blood*
Pregnancy
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CHI3L1 protein, human; 0/Glycoproteins; 0/Lectins; EC 3.2.1.-/Hexosaminidases; EC 3.2.1.-/chitotriosidase

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