| Chitotriosidase and YKL-40 in normal and pre-eclamptic pregnancies. | |
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MedLine Citation:
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PMID: 18054022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare macrophage activation in normal and pre-eclamptic pregnancies by determining YKL-40 concentration and chitotriosidase activity in maternal and cord serum. METHODS: In this prospective case-control study samples of maternal peripheral blood and umbilical venous blood were collected from 28 pre-eclamptic and 24 normotensive pregnant women and their newborns. YKL-40 concentration and chitotriosidase activity were determined by enzyme-linked immunoassay and fluorometry, respectively. RESULTS: Chitotriosidase activity in maternal and cord serum and YKL-40 concentration in cord serum were significantly higher in pre-eclamptic pregnancies (P<0.001), but there was no significant difference in maternal serum levels of YKL-40 between the case and control groups (P>0.05). There was a significant positive correlation between diastolic blood pressure and (1) chitotriosidase activity in both maternal and cord serum and (2) cord serum concentration of YKL-40 (r=0.61, r=0.84, and r=0.58, respectively). CONCLUSION: This study may be the first to demonstrate maternal and fetal macrophage activation in pre-eclampsia. |
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Authors:
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Riza Madazli; Mine Kucur; Altay Gezer; Ferruh Isman; Berk Bulut |
Publication Detail:
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Type: Journal Article Date: 2007-12-03 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 100 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-25 Completed Date: 2008-07-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 239-43 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, Istanbul, Turkey. madazli@superonline.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Blood Pressure / physiology Case-Control Studies Female Fetal Blood / chemistry* Glycoproteins / blood* Hexosaminidases / blood* Humans Infant, Newborn Lectins Macrophage Activation / physiology* Pre-Eclampsia / blood* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CHI3L1 protein, human; 0/Glycoproteins; 0/Lectins; EC 3.2.1.-/Hexosaminidases; EC 3.2.1.-/chitotriosidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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