Document Detail

Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger receptor BI and CYP7A1 in mice.
MedLine Citation:
PMID:  22302708     Owner:  NLM     Status:  MEDLINE    
Chitosan oligosaccharides (COS) are beneficial in improving plasma lipids and diminishing atherosclerotic risks. In this study, we examined the effects of COS on reverse cholesterol transport (RCT) in C57BL/6 mice. (3)H-cholesterol-laden macrophages were injected intraperitoneally into mice fed with various dosage of COS (250, 500, 1000 mg/kg mouse weight, respectively) or vehicle by gastric gavages. Plasma lipid level was determined and (3)H-cholesterol was traced in plasma, liver, bile and feces. The effects of COS on hepatic cholesterol 7 alpha-hydroxylase (CYP7A1) and scavenger receptor BI (SR-BI) expression were also investigated. COS administration led to a significant decrease in plasma total cholesterol and low-density lipoprotein (LDL) cholesterol and a significant increase in peritoneal macrophage-derived (3)H-cholesterol in liver and bile as well as in feces. Liver protein expressions of CYP7A1, SR-BI and LDL receptor (LDL-R) were improved in a dosage-dependent manner in COS-administered mice. Our findings provide the first in vivo demonstration of a positive role for COS in RCT pathway and hepatic CYP7A1 and SR-BI expression in mice. Additionally, the LDL cholesterol lowering effect might be relative to hepatic LDL-R expression stimulated by COS in mice.
Chuanlong Zong; Yang Yu; Guohua Song; Tian Luo; Luqin Li; Xinnong Wang; Shucun Qin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-02
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  237     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-22     Completed Date:  2012-04-09     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  194-200     Citation Subset:  IM    
Institute of Atherosclerosis, Taishan Medical University, Taian, China.
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MeSH Terms
Antigens, CD36 / genetics*
Atherosclerosis / metabolism
Biological Transport
Cell Line
Chitosan / chemistry*,  metabolism
Cholesterol / chemistry*,  metabolism
Cholesterol 7-alpha-Hydroxylase / genetics*
Liver / metabolism
Macrophages / cytology
Mice, Inbred C57BL
Models, Biological
Oligosaccharides / chemistry*
Reg. No./Substance:
0/Antigens, CD36; 0/Oligosaccharides; 57-88-5/Cholesterol; 9012-76-4/Chitosan; EC protein, human; EC 7-alpha-Hydroxylase

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