| Chitosan: a new hemostatic. | |
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MedLine Citation:
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PMID: 6222713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chitosan is a deacetylated derivative of arthropod chitin. We found that it formed a coagulum in contact with defibrinated blood, heparinized blood, and washed red cells. When knitted DeBakey grafts were treated with chitosan, they were impermeable to blood. Examination of these grafts at 24 hours revealed no rebleeding. Examination at one, two, three, and four months showed the grafts to be encased in smooth muscle with a living endothelial lining and an abundant vasa vasorum. Control grafts showed the usual fibrous healing. |
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Authors:
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W G Malette; H J Quigley; R D Gaines; N D Johnson; W G Rainer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 36 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1983 Jul |
Date Detail:
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Created Date: 1983-07-29 Completed Date: 1983-07-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 55-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta Blood Vessel Prosthesis Chitin / analogs & derivatives*, pharmacology Chitosan Dogs Hemostatics* Muscle, Smooth, Vascular / anatomy & histology Polyethylene Terephthalates Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Hemostatics; 0/Polyethylene Terephthalates; 1398-61-4/Chitin; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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