| Chitosan-glycolic acid: a possible matrix for progesterone delivery into skin. | |
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MedLine Citation:
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PMID: 19365777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chitosan-EDTA is an interesting matrix for dermal delivery; however, the adhesiveness is too small. Therefore, the purpose of this study was to investigate chitosan-glycolic acid as possible dermal matrix for progesterone in comparison to chitosan-EDTA and carrageenan. METHOD: After preparation of the chitosan-glycolic acid salt and characterization by NMR and FTIR, tensile studies using porcine skin and rheology measurements as well as standard diffusion experiments using dermatomed porcine skin were performed. RESULTS: Results showed an improved skin adhesiveness of chitosan-glycolic acid and increased viscosity. Skin diffusion studies indicated the highest cumulative permeation of progesterone after 48 hours from chitosan-glycolic acid followed by carrageenan and chitosan-EDTA. A possible explanation might be a longer residence time on skin caused by the higher adhesiveness and with it higher progesterone skin permeation. CONCLUSION: Chitosan-glycolic acid can be recommended as a suitable polymer for hydrogels and an adhesive matrix for a transdermal application of progesterone exhibiting excellent skin adhesiveness and permeation properties. |
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Authors:
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Hanspeter Kählig; Amra Hasanovic; Babette Biruss; Sonja Höller; Jutta Grim; Claudia Valenta |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Drug development and industrial pharmacy Volume: 35 ISSN: 1520-5762 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: England |
Other Details:
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Languages: eng Pagination: 997-1002 Citation Subset: IM |
Affiliation:
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Institute of Organic Chemistry, University of Vienna, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adhesiveness Administration, Cutaneous Animals Carrageenan / chemistry Chitosan / chemistry* Diffusion Drug Carriers / chemistry* Drug Delivery Systems Edetic Acid / chemistry Glycolates / chemistry* Permeability Progesterone / administration & dosage, pharmacokinetics* Skin Absorption Swine Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Glycolates; 57-83-0/Progesterone; 60-00-4/Edetic Acid; 79-14-1/glycolic acid; 9000-07-1/Carrageenan; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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