| Chitosan-sodium lauryl sulfate nanoparticles as a carrier system for the in vivo delivery of oral insulin. | |
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MedLine Citation:
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PMID: 21761276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present work explores the possibility of formulating an oral insulin delivery system using nanoparticulate complexes made from the interaction between biodegradable, natural polymer called chitosan and anionic surfactant called sodium lauryl sulfate (SLS). The interaction between chitosan and SLS was confirmed by Fourier transform infrared spectroscopy. The nanoparticles were prepared by simple gelation method under aqueous-based conditions. The nanoparticles were stable in simulated gastric fluids and could protect the encapsulated insulin from the GIT enzymes. Additionally, the in vivo results clearly indicated that the insulin-loaded nanoparticles could effectively reduce the blood glucose level in a diabetic rat model. However, additional formulation modifications are required to improve insulin oral bioavailability. |
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Authors:
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Amani Elsayed; Mayyas Al-Remawi; Nidal Qinna; Asim Farouk; Khaldoun A Al-Sou'od; Adnan A Badwan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-07-15 |
Journal Detail:
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Title: AAPS PharmSciTech Volume: 12 ISSN: 1530-9932 ISO Abbreviation: AAPS PharmSciTech Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-31 Completed Date: 2012-03-25 Revised Date: 2013-05-24 |
Medline Journal Info:
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Nlm Unique ID: 100960111 Medline TA: AAPS PharmSciTech Country: United States |
Other Details:
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Languages: eng Pagination: 958-64 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, Faculty of Pharmacy, Gezira University, Medani, Sudan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Biological Availability Blood Glucose / drug effects Chitosan / administration & dosage, chemistry* Diabetes Mellitus, Experimental / therapy* Drug Delivery Systems / methods Insulin / administration & dosage, chemistry*, pharmacokinetics*, therapeutic use Male Nanoparticles / administration & dosage, chemistry*, ultrastructure Particle Size Rats Rats, Wistar Sodium Dodecyl Sulfate / administration & dosage, chemistry* Spectroscopy, Fourier Transform Infrared Technology, Pharmaceutical / methods |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Insulin; 151-21-3/Sodium Dodecyl Sulfate; 9012-76-4/Chitosan |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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