| Chitosan iron(III) reduces phosphorus levels in alloxan diabetes-induced rats with signs of renal failure development. | |
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MedLine Citation:
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PMID: 20070292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluates the effect of complex cross-linked chitosan iron-(III) (CH-FeCL) polymer as phosphate binder in renal failure induced by alloxan (150 mg/kg, i.p.) in rats. The animals (male and female) were divided into four groups and received the treatment once a day for 15 days: (i) control group, which received a single injection of saline (3 ml/kg, i.p.) and normal diet; (ii) alloxan group, which received only a dose of alloxan and normal diet; (iii) phosphate (PO4) group, which received diet supplemented with phosphate 1.2%; and (iv) CH-FeCL group, which received diet supplemented with phosphate 1.2% + CH-FeCL 0.5% (0.054% Fe elemental). It was observed that the CH-FeCL treatment did not alter body-weight, relative weight of the organs and haematological parameters in the treated and control groups for both sexes. However, a decrease in serum phosphorus level of the CH-FeCL group was observed after 15 days, compared with the phosphate group in both sexes. The serum iron concentration of the CH-FeCL group did not differ from the control group in either sex. CH-FeCL polymer decreases intestinal phosphate absorption in rats with renal failure and is promising for the treatment of phosphate retention in patients with renal failure. |
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Authors:
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Lisiane M R Schöninger; Rafaela C Dall'Oglio; Silvana Sandri; Clóvis A Rodrigues; Cristiani Bürger |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-07 |
Journal Detail:
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Title: Basic & clinical pharmacology & toxicology Volume: 106 ISSN: 1742-7843 ISO Abbreviation: Basic Clin. Pharmacol. Toxicol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: Denmark |
Other Details:
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Languages: eng Pagination: 467-71 Citation Subset: IM |
Affiliation:
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Chemical-Pharmaceutical Investigations Center (NIQFAR/CCS), University of Itajaí Valley (UNIVALI), Itajaí, Santa Catarina, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alloxan Animals Chitosan / chemistry, pharmacology* Chlorides / chemistry, pharmacology* Cross-Linking Reagents Diabetes Mellitus, Experimental / complications Female Ferric Compounds / chemistry, pharmacology* Intestinal Absorption / drug effects Iron Kidney Failure / drug therapy*, etiology, physiopathology Male Phosphates / administration & dosage, metabolism* Phosphorus / blood Rats Rats, Wistar Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 0/Cross-Linking Reagents; 0/Ferric Compounds; 0/Phosphates; 50-71-5/Alloxan; 7439-89-6/Iron; 7705-08-0/ferric chloride; 7723-14-0/Phosphorus; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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