Document Detail

Chitosan Derivatives Cross-linked with Iodinated 2,5-Dimethoxy-2,5-dihydrofuran for Non-Invasive Imaging.
MedLine Citation:
PMID:  25265599     Owner:  NLM     Status:  Publisher    
Radiopaque polymer derivatives were successfully prepared through surface diffusion mediated cross-linking of chitosan with iodinated 2,5-Dimethoxy-2,5-dihydrofuran. Incorporation of iodine in 2,5-Dimethoxy-2,5-dihydrofuran was validated by 1H NMR and mass spectroscopy. The cross-linking of the glucosamine moieties of chitosan with the iodinated product was confirmed by 13C NMR and energy-dispersive X-ray spectroscopy. Radiography analysis proved inherent opacity of the iodinated fibrous sheets and microspheres that were comparable to the X-ray visibility of the aluminium hollow rings of equivalent thickness and commercially available radiopaque tape, respectively. Microscopic studies evidenced retention of the fiber/microsphere morphology after the iodination/cross-linking reactions. The effects of iodination/cross-linking on the mechanical and biodegradation properties of the fibers were studied by nanoindentation and enzymatic assay, respectively. In vitro/in vivo studies established nontoxic, biodegradable nature of the radiopaque derivatives. The iodinated fiber mesh implanted in a rabbit model was significantly X-ray opaque compared to the uncross-linked fiber mesh and medical grade surgical swabs. Further, opacity of the iodinated mesh was evident even after 60 days, though the intensity was reduced indicating biodegradable nature of the iodinated polymer. The opacity of the iodinated sutures were also established in the CT images. Finally, sufficient in vivo contrast property of the radiopaque microspheres in the gastrointestinal tract indicates its possible role in clinical diagnostics.
Paulomi Ghosh; Manisit Das; Arun Prabhu Rameshbabu; Dipankar Das; Sayanti Datta; Sagar Pal; Asit Baran Panda; Santanu Dhara
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-29
Journal Detail:
Title:  ACS applied materials & interfaces     Volume:  -     ISSN:  1944-8252     ISO Abbreviation:  ACS Appl Mater Interfaces     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-29     Completed Date:  -     Revised Date:  2014-9-30    
Medline Journal Info:
Nlm Unique ID:  101504991     Medline TA:  ACS Appl Mater Interfaces     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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